Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris
- PMID: 15310528
- DOI: 10.1016/j.humimm.2004.05.008
Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris
Abstract
Psoriasis vulgaris, particularly its juvenile form, is strongly associated with the HLA-Cw*06 allele encoding the HLA-Cw6 molecule. This molecule is recognized by the inhibitory receptor KIR2DL1 and the activatory receptor KIR2DS1, which are expressed on natural killer cells and subpopulations of T lymphocytes. Humans differ by the presence or absence of particular KIR genes. We hypothesized that either activatory KIR2DS1 or inhibitory KIR2DL1 gene frequencies might be different in psoriatic patients from a control population. Therefore, we compared the frequencies of KIR2D inhibitory (L) and activatory (S) genes in 116 psoriasis vulgaris patients and in 123 healthy controls. Fourteen novel gene combinations were found. KIR2DS1 was present in 85% of the patients, but only in 51% of the controls (corrected p [pc] < 0.0009). Similarly, HLA-Cw*06 was much more frequent in patients (77%) than in controls (17%; pc < 0.00002). Statistical analysis suggests that, although the contribution of these two factors to psoriasis is partially independent, they interact nevertheless. This result strongly speaks for a role of KIR2DS1 on recognition of HLA-Cw6 in susceptibility to psoriasis.
Similar articles
-
A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris.Tissue Antigens. 2008 Oct;72(4):392-6. doi: 10.1111/j.1399-0039.2008.01096.x. Epub 2008 Jul 15. Tissue Antigens. 2008. PMID: 18643961
-
A role for KIR gene variants other than KIR2DS1 in conferring susceptibility to psoriasis.Hum Immunol. 2006 Jul;67(7):521-6. doi: 10.1016/j.humimm.2006.04.001. Epub 2006 May 3. Hum Immunol. 2006. PMID: 16829306
-
Increased activating killer immunoglobulin-like receptor genes and decreased specific HLA-C alleles in couples with recurrent spontaneous abortion.Biochem Biophys Res Commun. 2007 Aug 31;360(3):696-701. doi: 10.1016/j.bbrc.2007.06.125. Epub 2007 Jul 2. Biochem Biophys Res Commun. 2007. PMID: 17617375
-
Human leukocyte antigens as psoriasis inheritance and susceptibility markers.Arch Immunol Ther Exp (Warsz). 2005 Sep-Oct;53(5):428-33. Arch Immunol Ther Exp (Warsz). 2005. PMID: 16314826 Review.
-
Associations between KIR epitope combinations expressed by HLA-B/-C haplotypes found in an HIV-1 infected study population may influence NK mediated immune responses.Mol Immunol. 2005 Feb;42(4):557-60. doi: 10.1016/j.molimm.2004.07.041. Mol Immunol. 2005. PMID: 15607813 Review.
Cited by
-
The tortoise and the hare: slowly evolving T-cell responses take hastily evolving KIR.Immunology. 2010 Nov;131(3):301-9. doi: 10.1111/j.1365-2567.2010.03337.x. Epub 2010 Aug 17. Immunology. 2010. PMID: 20722764 Free PMC article. Review.
-
Natural killer cell immunoglobulin-like receptors (KIR) genotypes in two arab populations: will KIR become a genetic landmark between nations?Mol Biol Rep. 2008 Jun;35(2):225-9. doi: 10.1007/s11033-007-9074-6. Epub 2007 Mar 26. Mol Biol Rep. 2008. PMID: 17385087
-
Understanding how combinations of HLA and KIR genes influence disease.J Exp Med. 2005 Apr 4;201(7):1025-9. doi: 10.1084/jem.20050499. J Exp Med. 2005. PMID: 15809348 Free PMC article. Review.
-
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene.Am J Hum Genet. 2006 May;78(5):827-851. doi: 10.1086/503821. Epub 2006 Mar 31. Am J Hum Genet. 2006. PMID: 16642438 Free PMC article.
-
Protective KIR-HLA interactions for HCV infection in intravenous drug users.Mol Immunol. 2009 Aug;46(13):2723-7. doi: 10.1016/j.molimm.2009.05.014. Epub 2009 Jun 24. Mol Immunol. 2009. PMID: 19552960 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
