Physiology of folate and vitamin B12 in health and disease
- PMID: 15298442
- DOI: 10.1111/j.1753-4887.2004.tb00070.x
Physiology of folate and vitamin B12 in health and disease
Abstract
Folate is a water-soluble B-vitamin and enzymatic cofactor that is necessary for the synthesis of purine and thymidine nucleotides and for the synthesis of methionine from homocysteine. Impairment of folate-mediated one-carbon metabolic pathways can result from B-vitamin deficiencies and/or single nucleotide polymorphisms, and increases risk for pathologies, including cancer and cardiovascular disease, and developmental anomalies including neural tube defects. Although several well validated metabolic and genomic biomarkers for folate deficiency exist, our understanding of the biochemical and genetic mechanisms whereby impaired folate metabolism increases risk for developmental anomalies and disease is limited, as are the mechanisms whereby elevated folate intake protects against these pathologies. Therefore, current initiatives to increase folate intakes in human populations to ameliorate developmental anomalies and prevent disease, while effective, lack predictive value with respect to unintended adverse outcomes.
Similar articles
-
Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome.Br J Nutr. 2001 May;85 Suppl 2:S109-13. Br J Nutr. 2001. PMID: 11509098 Review.
-
Folate, vitamin B12 and homocysteine status in women of childbearing age: baseline data of folic acid wheat flour fortification in Iran.Ann Nutr Metab. 2008;53(2):143-50. doi: 10.1159/000170890. Epub 2008 Nov 10. Ann Nutr Metab. 2008. PMID: 18997463
-
Folate and vitamin B12: function and importance in cognitive development.Nestle Nutr Inst Workshop Ser. 2012;70:161-71. doi: 10.1159/000337684. Epub 2012 Aug 31. Nestle Nutr Inst Workshop Ser. 2012. PMID: 25825305
-
[Folate, vitamin B12 and human health].Rev Med Chil. 2012 Nov;140(11):1464-75. doi: 10.4067/S0034-98872012001100014. Rev Med Chil. 2012. PMID: 23677195 Review. Spanish.
-
Research goals for folate and related B vitamin in Europe.Eur J Clin Nutr. 2006 Feb;60(2):287-94. doi: 10.1038/sj.ejcn.1602315. Eur J Clin Nutr. 2006. PMID: 16251882 Review.
Cited by
-
Hereditary Folate Malabsorption presenting as neutropenic fever in a newborn from the first Palestinian family with the novel SLC46A1-mutation, A-case-report.Ann Med Surg (Lond). 2022 Jul 31;80:104253. doi: 10.1016/j.amsu.2022.104253. eCollection 2022 Aug. Ann Med Surg (Lond). 2022. PMID: 36045837 Free PMC article.
-
Stearoyl-CoA Desaturase-1: Is It the Link between Sulfur Amino Acids and Lipid Metabolism?Biology (Basel). 2015 Jun 3;4(2):383-96. doi: 10.3390/biology4020383. Biology (Basel). 2015. PMID: 26046927 Free PMC article. Review.
-
Plasma metabolite profiles in healthy women differ after intervention with supplemental folic acid v. folate-rich foods.J Nutr Sci. 2018 Nov 26;7:e32. doi: 10.1017/jns.2018.22. eCollection 2018. J Nutr Sci. 2018. PMID: 30510697 Free PMC article.
-
Vitamin B12 Status of Various Ethnic Groups Living in New Zealand: An Analysis of the Adult Nutrition Survey 2008/2009.Nutrients. 2018 Feb 7;10(2):181. doi: 10.3390/nu10020181. Nutrients. 2018. PMID: 29414857 Free PMC article.
-
Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency.J Biol Chem. 2014 Oct 24;289(43):29642-50. doi: 10.1074/jbc.M114.599589. Epub 2014 Sep 11. J Biol Chem. 2014. PMID: 25213861 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
