From magic bullets to designed multiple ligands
- PMID: 15279847
- DOI: 10.1016/S1359-6446(04)03163-0
From magic bullets to designed multiple ligands
Abstract
Increasingly, it is being recognised that a balanced modulation of several targets can provide a superior therapeutic effect and side effect profile compared to the action of a selective ligand. Rational approaches in which structural features from selective ligands are combined have produced designed multiple ligands that span a wide variety of targets and target classes. A key challenge in the design of multiple ligands is attaining a balanced activity at each target of interest while simultaneously achieving a wider selectivity and a suitable pharmacokinetic profile. An analysis of literature examples reveals trends and insights that might help medicinal chemists discover the next generation of these types of compounds.
Comment in
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Multitargeted drugs: the end of the "one-target-one-disease" philosophy?Drug Discov Today. 2004 Oct 1;9(19):826-7. doi: 10.1016/S1359-6446(04)03213-1. Drug Discov Today. 2004. PMID: 15381132 No abstract available.
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Turning from monogamy to strategic promiscuity.Drug Discov Today. 2004 Sep 1;9(17):736-7. doi: 10.1016/S1359-6446(04)03208-8. Drug Discov Today. 2004. PMID: 15450238 No abstract available.
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