Clinical Trial
doi: 10.1038/nm1077.
Epub 2004 Jul 11.
A role for Streptococcus pneumoniae in virus-associated pneumonia
Affiliations
- PMID: 15247911
- PMCID: PMC7095883
- DOI: 10.1038/nm1077
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Clinical Trial
A role for Streptococcus pneumoniae in virus-associated pneumonia
Nat Med.
2004 Aug.
Abstract
Here we show, in a double-blind, randomized, placebo-controlled trial in 37,107 fully immunized infants in Soweto, South Africa, that a 9-valent pneumococcal conjugate vaccine, PncCV, prevents 31% (95% confidence interval = 15-43%) of pneumonias associated with any of seven respiratory viruses in children in hospital. These data suggest that the pneumococcus has a major role in the development of pneumonia associated with these viruses and that viruses contribute to the pathogenesis of bacterial pneumonia.
Conflict of interest statement
Vaccine trial was funded by Wyeth.
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References
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- Pneumonia Vaccine Trial Investigators' Group. Standardization of Interpretation of Chest Radiographs for the Diagnosis of Pneumonia in Children (Department of Vaccines and Biologicals, WHO, Geneva, 2001).
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