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Review
. 2004 Jul;34(7):667-71.
doi: 10.1016/j.ibmb.2004.03.019.

Mosquito midgut barriers to malaria parasite development

Affiliations
Review

Mosquito midgut barriers to malaria parasite development

Eappen G Abraham et al. Insect Biochem Mol Biol. 2004 Jul.

Abstract

Malaria is one of the deadliest infectious diseases and kills more than one million people every year. For transmission to occur, the malaria parasite has to complete an elaborate developmental program in hostile mosquito environment. Thus, understanding the molecular mechanisms by which mosquitoes limit the parasite development may lead to new methods for controlling malaria. There has been considerable progress during the last decade in this research area. This review focuses on the mosquito response to midgut invasion of the malaria parasite and examines the role of mosquito digestive enzymes, peritrophic matrix and microvillar proteins as barriers to parasite development.

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