Review
doi: 10.1002/jps.20096.
Release from polymeric prodrugs: linkages and their degradation
Affiliations
- PMID: 15236447
- DOI: 10.1002/jps.20096
Item in Clipboard
Review
Release from polymeric prodrugs: linkages and their degradation
J Pharm Sci.
2004 Aug.
Abstract
Polymeric prodrugs have evolved into a very useful class of drug delivery agents. Numerous polymeric prodrugs have been prepared for applications ranging from passive drug targeting to controlled release. The mechanistic aspects of the release processes, however, have not been clearly delineated. This review highlights the salient features of the chemical reactions that are responsible for drug release from these systems. The mechanisms of release from polymeric prodrugs employing various chemical linkages, esters, carbonates, carbamates, C=N linkage and amides, are discussed.
Copyright 2004 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 93:1962-1979, 2004
Similar articles
-
Polymeric prodrugs.Int J Pharm. 2004 Jun 11;277(1-2):119-31. doi: 10.1016/j.ijpharm.2003.07.016. Int J Pharm. 2004. PMID: 15158975 Review.
-
Polymeric prodrugs.Crit Rev Ther Drug Carrier Syst. 1987;4(1):39-65. Crit Rev Ther Drug Carrier Syst. 1987. PMID: 3315236 Review.
-
Release of 5-amino salicylic acid from acrylic type polymeric prodrugs designed for colon-specific drug delivery.J Control Release. 1999 Apr 19;58(3):279-87. doi: 10.1016/s0168-3659(98)00167-9. J Control Release. 1999. PMID: 10099153
-
Mechanochemical solid-state polymerization. IX. Theoretical analysis of rate of drug release from powdered polymeric prodrugs in a heterogeneous system.Chem Pharm Bull (Tokyo). 1998 Dec;46(12):1918-23. doi: 10.1248/cpb.46.1918. Chem Pharm Bull (Tokyo). 1998. PMID: 9880912
-
The Hydrolysis of Diclofenac Esters: Synthetic Prodrug Building Blocks for Biodegradable Drug-Polymer Conjugates.J Pharm Sci. 2016 Feb;105(2):773-785. doi: 10.1002/jps.24665. Epub 2016 Jan 29. J Pharm Sci. 2016. PMID: 26540508
Cited by
-
Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imaging.Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13872-7. doi: 10.1073/pnas.0601455103. Epub 2006 Sep 1. Proc Natl Acad Sci U S A. 2006. PMID: 16950881 Free PMC article.
-
Fabrication of chitosan-bis (4-formyl-2 methoxy phenyl carbonate) Schiff base nanoparticles and evaluation of their antioxidant and anticancer properties.Mol Biol Rep. 2019 Aug;46(4):4333-4347. doi: 10.1007/s11033-019-04887-4. Epub 2019 May 21. Mol Biol Rep. 2019. PMID: 31115838
-
Side chain effect in the modulation of αvβ3/α5β1 integrin activity via clickable isoxazoline-RGD-mimetics: development of molecular delivery systems.Sci Rep. 2020 May 4;10(1):7410. doi: 10.1038/s41598-020-64396-4. Sci Rep. 2020. PMID: 32366988 Free PMC article.
-
Low-molecular-weight polymer-drug conjugates for synergistic anticancer activity of camptothecin and doxorubicin combinations.Nanomedicine (Lond). 2016 May;11(9):1139-51. doi: 10.2217/nnm.16.33. Epub 2016 Apr 15. Nanomedicine (Lond). 2016. PMID: 27079141 Free PMC article.
-
Dual pH- and GSH-Responsive Degradable PEGylated Graphene Quantum Dot-Based Nanoparticles for Enhanced HER2-Positive Breast Cancer Therapy.Nanomaterials (Basel). 2020 Jan 2;10(1):91. doi: 10.3390/nano10010091. Nanomaterials (Basel). 2020. PMID: 31906509 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
