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. 2004 May;10(5):899-902.
doi: 10.3201/eid1005.030964.

Novel gamma-2-herpesvirus of the Rhadinovirus 2 lineage in gibbons

Renan Duprez  1 , Emmanuelle Boulanger, Yannick Roman, Antoine Gessain
Affiliations

Novel gamma-2-herpesvirus of the Rhadinovirus 2 lineage in gibbons

Renan Duprez et al. Emerg Infect Dis. 2004 May.

Abstract

We obtained 475 nucleotides of the DNA polymerase gene of a novel human herpesvirus 8 homolog sequence in a gibbon. The finding of this new gibbon virus, which clusters with a related chimpanzee virus in the rhadinovirus 2 genogroup, suggests the existence of a novel gamma-2-herpesvirus in humans.

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Figures

Figure 1
Figure 1
Neighbor-joining protein distance tree for the best 130 amino acids of DNA polymerase residues alignment. DNA sequences (primers DFASA and GDTD1B) (8) were first translated, then aligned by using ClustalX (nonphylogeneticaly informative gaps were manually removed) and analyzed by using the PROTDIST and NEIGHBOR programs in PHYLIP (available from: http://evolution.genetics.washington.edu/phylip.html). Horizontal branch lengths are drawn to scale, with the bar indicating 0.1 amino acid replacements per site. Numbers in each internal branch indicate the percentage of bootstrap samples (of 1,000) in which the cluster is supported (SEQBOOT). Previously published sequences included and their accession numbers are as follows: HyloRHV2 (AY465375); PanRHV2 (AF346490); KSHV (U75698, U93872 and AF005477); PanRHV1a (AF250879 and AF250880); PanRHV1b (AF250881 and AF250882); GorRHV1 (AF250886); MndRHV1 (AF282943); MndRHV2 (AF282937 to AF282940); herpesvirus saimiri (HVS) (M31122); ateline herpesvirus 3 (HVA3) (AF083424); Chlorocebus rhadinovirus 1 (ChRV1) (AJ251573); ChRV2 (AJ251574); retroperitoneal fibromatosis–associated herpesvirus strains from Macaca mulatta (AF005479) and M. nemestrina (AF005478) called here RFHVMm and RFHVMn, respectively; M. mulatta rhadinovirus RRV/17577 (AF083501); rhesus monkey rhadinovirus (RRV/H26-95) (AF029302); baboon γ-herpesvirus (PapRV2) (AY270026); Macaca γ-virus strains from M. mulatta (MGVMm) (AF159033), M. fascicularis (MGVMf) (AF159032), and M. nemestrina (AF159031); and HHV6A (X83413). Other sequences used to construct the phylogenetic trees (especially Epstein-Barr virus and related strains) have been published mainly by Ehlers et al. (9) and are named in the legend of Figure 2.
Figure 2
Figure 2
Phylogenetic tree resulting from analysis of selected 351-bp fragments of herpesvirus DNA polymerase gene, which is available for all viruses. The DNA sequences were first aligned by using ClustalX (nonphylogeneticaly informative gaps were manually removed), then the phylogeny was derived by the neighbor-joining method applied to pairwise sequence distances calculated by the Kimura two-parameter method (transition-to-transversion ratio set at 1.15 as expected by a previous Maximum Likelihood analysis). Horizontal branch lengths are drawn to scale, with the bar indicating 0.1 nucleotide replacements per site. Numbers at each node indicate the percentage of bootstrap samples (of 1,000) in which the cluster to the right is supported. Brackets on the right indicate previously defined subfamily and genus herpesviral classification. Previously published sequences and their accession numbers are described online at: http://www.cdc.gov/ncidod/EID/vol10no5/03-0964-G2.htm
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