Review
doi: 10.1016/j.cub.2004.05.012.
LKB1 kinase: master and commander of metabolism and polarity
Affiliations
- PMID: 15186763
- DOI: 10.1016/j.cub.2004.05.012
Item in Clipboard
Review
LKB1 kinase: master and commander of metabolism and polarity
Curr Biol.
.
Free article
Abstract
LKB1, the product of a tumour suppressor gene, is a serine/threonine kinase that coordinates disparate cellular processes. Recent data have revealed novel functions for LKB1, providing new insight into the regulation of cell polarity and energy-generating metabolism.
Similar articles
-
LKB1, the multitasking tumour suppressor kinase.J Clin Pathol. 2005 Jan;58(1):15-9. doi: 10.1136/jcp.2003.015255. J Clin Pathol. 2005. PMID: 15623475 Free PMC article. Review.
-
LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.Physiol Rev. 2009 Jul;89(3):777-98. doi: 10.1152/physrev.00026.2008. Physiol Rev. 2009. PMID: 19584313 Review.
-
The LKB1 tumor suppressor kinase in human disease.Biochim Biophys Acta. 2007 Jan;1775(1):63-75. doi: 10.1016/j.bbcan.2006.08.003. Epub 2006 Aug 16. Biochim Biophys Acta. 2007. PMID: 17010524 Review.
-
Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.Hum Mol Genet. 2005 May 15;14(10):1283-92. doi: 10.1093/hmg/ddi139. Epub 2005 Mar 30. Hum Mol Genet. 2005. PMID: 15800014
-
LKB1-dependent signaling pathways.Annu Rev Biochem. 2006;75:137-63. doi: 10.1146/annurev.biochem.75.103004.142702. Annu Rev Biochem. 2006. PMID: 16756488 Review.
Cited by
-
The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels.Genes Dev. 2008 Sep 15;22(18):2447-53. doi: 10.1101/gad.1724108. Genes Dev. 2008. PMID: 18794342 Free PMC article. Review.
-
The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo.Commun Biol. 2021 Jan 29;4(1):142. doi: 10.1038/s42003-021-01663-8. Commun Biol. 2021. PMID: 33514834 Free PMC article.
-
No association between promoter polymorphism of STK11 gene and lung cancer risk in the Korean population.Cancer Res Treat. 2009 Dec;41(4):211-7. doi: 10.4143/crt.2009.41.4.211. Epub 2009 Dec 31. Cancer Res Treat. 2009. PMID: 20057966 Free PMC article.
-
Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2.BMC Biochem. 2010 Sep 21;11:36. doi: 10.1186/1471-2091-11-36. BMC Biochem. 2010. PMID: 20858278 Free PMC article.
-
Targeting the LKB1 tumor suppressor.Curr Drug Targets. 2014 Jan;15(1):32-52. doi: 10.2174/1389450114666140106095811. Curr Drug Targets. 2014. PMID: 24387336 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
