Reciprocal influences between the signalling pathways regulating proliferation and steroidogenesis in adrenal glomerulosa cells
- PMID: 15171720
- DOI: 10.1677/jme.0.0320893
Reciprocal influences between the signalling pathways regulating proliferation and steroidogenesis in adrenal glomerulosa cells
Abstract
The main regulators of aldosterone secretion in adrenal gland zona glomerulosa (ZG) cells are the hormones angiotensin II (Ang II) and adrenocorticotrophin (ACTH) and small increases in the extracellular potassium (K(+)) concentration. The action of these agonists is mediated by different signalling systems - ACTH is mediated by cAMP and activation of protein kinase A while Ang II and K(+) activate two protein kinases, Ca(2+)-calmodulin-dependent protein kinase (CamK) and diacylglycerol-dependent protein kinase (PKC). Ang II, besides being one of the main agonists for the secretion of aldosterone, also stimulates proliferation of ZG cells, a process mediated by mitogen-activated protein kinases (MAPKs). Recent studies aimed at elucidating the molecular mechanisms underlying cell proliferation have shown that calcineurin is the principal regulator of MAPKs activity. The purpose of this review is to discuss experimental evidence of possible reciprocal influences between the signalling pathways regulating proliferation and steroidogenesis in ZG cells.
Similar articles
-
Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP.Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E423-33. doi: 10.1152/ajpendo.00128.2005. Epub 2005 Oct 11. Am J Physiol Endocrinol Metab. 2006. PMID: 16219670
-
Regulators of G-protein signaling 4 in adrenal gland: localization, regulation, and role in aldosterone secretion.J Endocrinol. 2007 Aug;194(2):429-40. doi: 10.1677/JOE-07-0153. J Endocrinol. 2007. PMID: 17641290
-
Demonstration of an angiotensin II-induced negative feedback effect on aldosterone synthesis in isolated rat adrenal zona glomerulosa cells.Mol Cell Endocrinol. 1996 May 17;119(1):105-11. doi: 10.1016/0303-7207(96)03805-1. Mol Cell Endocrinol. 1996. PMID: 8793859
-
Role of MAPKs in angiotensin II-induced steroidogenesis in rat glomerulosa cells.Mol Cell Endocrinol. 2007 Feb;265-266:126-30. doi: 10.1016/j.mce.2006.12.008. Epub 2007 Jan 9. Mol Cell Endocrinol. 2007. PMID: 17215073 Review.
-
Control of aldosterone secretion: a model for convergence in cellular signaling pathways.Physiol Rev. 2004 Apr;84(2):489-539. doi: 10.1152/physrev.00030.2003. Physiol Rev. 2004. PMID: 15044681 Review.
Cited by
-
A role for phospholipase D in angiotensin II-induced protein kinase D activation in adrenal glomerulosa cell models.Mol Cell Endocrinol. 2013 Feb 5;366(1):31-7. doi: 10.1016/j.mce.2012.11.008. Epub 2012 Nov 20. Mol Cell Endocrinol. 2013. PMID: 23178798 Free PMC article.
-
Tumor necrosis factor-α regulates glucocorticoid synthesis in the adrenal glands of Trypanosoma cruzi acutely-infected mice. the role of TNF-R1.PLoS One. 2013 May 22;8(5):e63814. doi: 10.1371/journal.pone.0063814. Print 2013. PLoS One. 2013. PMID: 23717489 Free PMC article.
-
The interplay between bioactive sphingolipids and steroid hormones.Steroids. 2010 Jun;75(6):390-9. doi: 10.1016/j.steroids.2010.01.020. Epub 2010 Feb 4. Steroids. 2010. PMID: 20138078 Free PMC article. Review.
-
Orexins stimulate steroidogenic acute regulatory protein expression through multiple signaling pathways in human adrenal H295R cells.Endocrinology. 2008 Aug;149(8):4106-15. doi: 10.1210/en.2007-1739. Epub 2008 May 1. Endocrinology. 2008. PMID: 18450961 Free PMC article.
-
Mechanisms of endothelin-1-induced MAP kinase activation in adrenal glomerulosa cells.J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):79-88. doi: 10.1016/j.jsbmb.2006.09.026. J Steroid Biochem Mol Biol. 2006. PMID: 17113976 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
