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Multicenter Study
. 2004 May 22;363(9422):1699-700.
doi: 10.1016/S0140-6736(04)16255-7.

Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome

Peter K C Cheng  1 , Derek A Wong, Louis K L Tong, Sin-Ming Ip, Angus C T Lo, Chi-Shan Lau, Eugene Y H Yeung, Wilina W L Lim
Affiliations
Multicenter Study

Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome

Peter K C Cheng et al. Lancet. .

Abstract

Severe acute respiratory syndrome (SARS) is thought to be caused by a novel coronavirus, SARS-associated coronavirus. We studied viral shedding of SARS coronavirus to improve diagnosis and infection control. Reverse-transcriptase PCR was done on 2134 specimens of different types. 355 (45%) specimens of nasopharyngeal aspirates and 150 (28%) of faeces were positive for SARS coronavirus RNA. Positive rates peaked at 6-11 days after onset of illness for nasopharyngeal aspirates (87 of 149 [58%], to 37 of 62 [60%]), and 9-14 days for faeces (15 of 22 [68%], to 26 of 37 [70%]). Overall, peak viral loads were reached at 12-14 days of illness when patients were probably in hospital care, which would explain why hospital workers were prone to infection. Low rate of viral shedding in the first few days of illness meant that early isolation measures would probably be effective.

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References

    1. WHO Severe acute respiratory syndrome (SARS): multi-country outbreak—update 34. http://www.who.int/csr/don/2003_04_19/en/ (accessed March 22, 2004).
    1. Peiris JSM, Lai ST, Poon LL. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361:1319–1325. - PMC - PubMed
    1. Peiris JSM, Chu CM, Cheng VCC. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet. 2003;361:1767–1772. - PMC - PubMed
    1. WHO Case definitions for surveillance of severe acute respiratory syndrome (SARS) http://www.who.int/csr/sars/casedefinition/en/ (accessed March 22, 2004).
    1. Tsang OT, Chau TN, Choi KW. Coronavirus-positive nasopharyngeal aspirate as predictor for severe acute respiratory syndrome mortality. Emerg Infect Dis. 2003;9:1381–1387. - PMC - PubMed

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