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Review
. 2004 Jun;16(3):264-70.
doi: 10.1016/j.coi.2004.03.015.

The CD8 isoform CD8alphaalpha is not a functional homologue of the TCR co-receptor CD8alphabeta

Denise Gangadharan  1 , Hilde Cheroutre
Affiliations
Review

The CD8 isoform CD8alphaalpha is not a functional homologue of the TCR co-receptor CD8alphabeta

Denise Gangadharan et al. Curr Opin Immunol. 2004 Jun.

Abstract

Although structurally similar, CD8alphabeta and CD8alphaalpha have notably diverted with regard to function. Whereas CD8alphabeta functions as a T-cell receptor (TCR) co-receptor on MHC-class-I-restricted thymocytes and mature T cells, CD8alphaalpha is unable to support conventional positive selection, and can be expressed on T cells independent of the MHC restriction of their TCR. CD8alphaalpha induction is consistent with antigenic stimulation through the TCR, and recent developments have now shown that CD8alphaalpha induced on agonist-triggered immature thymocytes, antigenic-stimulated conventional CD8alphabeta T cells and mucosal T cells mediates the specific modulation of TCR activation signals to facilitate their survival and differentiation into various specialized T-cell subsets.

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