Review
doi: 10.1007/s00280-004-0778-1.
Epub 2004 Apr 29.
Three steps to cancer: how phosphorylation of tubulin, tubulin tyrosine ligase and P-glycoprotein may generate and sustain cancer
Affiliations
- PMID: 15118838
- DOI: 10.1007/s00280-004-0778-1
Item in Clipboard
Review
Three steps to cancer: how phosphorylation of tubulin, tubulin tyrosine ligase and P-glycoprotein may generate and sustain cancer
Cancer Chemother Pharmacol.
2004 Aug.
Abstract
Transformed cells progress to cancer because they are not eliminated by apoptosis. In this brief minireview I propose, based on published data, that the cell possesses a 'last check point' (LCP) apoptotic step in the form of assembly of nitrotyrosinated alpha-tubulin onto microtubules. This leads to microtubule dysfunction and ultimately apoptosis. I also propose that cells that escape this LCP apoptotic step develop into cancer. Phosphorylation of tubulin tyrosine ligase (TTL) is postulated to cause escape from LCP apoptosis. Phosphorylation also ensures that cancer cells survive a hostile milieu (e.g. chemotherapy).
Similar articles
-
Phosphorylation of tubulin tyrosine ligase: a potential mechanism for regulation of alpha-tubulin tyrosination.Cell Motil Cytoskeleton. 2000 May;46(1):1-5. doi: 10.1002/(SICI)1097-0169(200005)46:1<1::AID-CM1>3.0.CO;2-6. Cell Motil Cytoskeleton. 2000. PMID: 10842328 Review.
-
Microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination.Dev Neurosci. 2008;30(1-3):200-10. doi: 10.1159/000109863. Dev Neurosci. 2008. PMID: 18075266
-
Normal and prostate cancer cells display distinct molecular profiles of alpha-tubulin posttranslational modifications.Prostate. 2006 Jun 15;66(9):954-65. doi: 10.1002/pros.20416. Prostate. 2006. PMID: 16541425
-
Potential role of tubulin tyrosine ligase-like enzymes in tumorigenesis and cancer cell resistance.Cancer Lett. 2014 Aug 1;350(1-2):1-4. doi: 10.1016/j.canlet.2014.04.022. Epub 2014 May 6. Cancer Lett. 2014. PMID: 24814394 Review.
-
Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability.Biochemistry. 2004 Nov 9;43(44):13944-54. doi: 10.1021/bi049300+. Biochemistry. 2004. PMID: 15518543
Cited by
-
Protein Signatures in Human MDA-MB-231 Breast Cancer Cells Indicating a More Invasive Phenotype Following Knockdown of Human Endometase/Matrilysin-2 by siRNA.J Cancer. 2011 Mar 16;2:165-76. doi: 10.7150/jca.2.165. J Cancer. 2011. PMID: 21475635 Free PMC article.
-
Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes.Mol Cancer Ther. 2011 Aug;10(8):1419-29. doi: 10.1158/1535-7163.MCT-10-1057. Epub 2011 Jun 8. Mol Cancer Ther. 2011. PMID: 21653684 Free PMC article.
-
Predicting phosphorylation sites using machine learning by integrating the sequence, structure, and functional information of proteins.J Transl Med. 2021 May 24;19(1):218. doi: 10.1186/s12967-021-02851-0. J Transl Med. 2021. PMID: 34030700 Free PMC article.
-
Effect of TTLL6 expression on CDDP sensitivity of EC109/CDDP cells in hypoxia/acidosis microenvironment.J Cancer. 2020 Sep 30;11(23):6790-6801. doi: 10.7150/jca.47694. eCollection 2020. J Cancer. 2020. PMID: 33123270 Free PMC article.
-
TTLL12 has a potential oncogenic activity, suppression of ligation of nitrotyrosine to the C-terminus of detyrosinated α-tubulin, that can be overcome by molecules identified by screening a compound library.PLoS One. 2024 Feb 23;19(2):e0296960. doi: 10.1371/journal.pone.0296960. eCollection 2024. PLoS One. 2024. PMID: 38394155 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
