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. 2004 Mar;10(3):478-82.
doi: 10.3201/eid1003.020821.

Neutralizing antibodies and Sin Nombre virus RNA after recovery from hantavirus cardiopulmonary syndrome

Chunyan Ye  1 , Joseph Prescott, Robert Nofchissey, Diane Goade, Brian Hjelle
Affiliations

Neutralizing antibodies and Sin Nombre virus RNA after recovery from hantavirus cardiopulmonary syndrome

Chunyan Ye et al. Emerg Infect Dis. 2004 Mar.

Abstract

Patients who later have a mild course of hantavirus cardiopulmonary syndrome (HCPS) are more likely to exhibit a high titer of neutralizing antibodies against Sin Nombre virus (SNV), the etiologic agent of HCPS, at the time of hospital admission. Because administering plasma from patients who have recovered from HCPS to those in the early stages of disease may be an advantageous form of passive immunotherapy, we examined the neutralizing antibody titers of 21 patients who had recovered from SNV infection. Even 1,000 days after admission to the hospital, 6 of 10 patients had titers of 800 or higher, with one sample retaining a titer of 3,200 after more than 1,400 days. None of the convalescent-phase serum samples contained detectable viral RNA. These results confirm that patients retain high titers of neutralizing antibodies long after recovery from SNV infection.

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Figures

Figure
Figure
Titers of neutralizing antibodies against Sin Nombre virus (SNV) strain SN77734 in serum samples from patients surviving hantavirus cardiopulmonary syndrome due to SNV. The reciprocal of the endpoint neutralization titer is plotted for each sample. Numbers near certain clusters of points reflect the number of individual data points represented in a particular cluster.
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