[Nebulized budesonide to treat acute asthma in children]
- PMID: 15079179
[Nebulized budesonide to treat acute asthma in children]
Abstract
Objective: To investigate the efficacy of a single dose of inhaled budesonide as compared to oral prednisone in patients with acute asthma.
Methods: Randomized double-blind, double-dummy and placebo-controlled clinical trial. Forty-nine children aged 2 to 7 years with acute asthma were randomized in three groups after receiving nebulized salbutamol (0.15 mg/kg). Group I received placebo both as tablets and nebulization, group II was treated with a single dose of oral prednisone (1 mg/kg) and inhaled placebo, and group III received a single dose of placebo tablet and nebulized budesonide (2 mg). Patients were evaluated in terms of symptom score and transcutaneous hemoglobin saturation. Nebulized salbutamol was repeated in case of increasing symptom score or lower saturation.
Results: Progressive clinical improvement was observed in all three groups. However, a significant increase in hemoglobin saturation was observed after 2 hours with prednisone, 4 hours with budesonide, and 24 hours with placebo.
Conclusion: A combination of single-dose nebulized budesonide and salbutamol may be as effective as oral prednisone to improve symptom severity, but the latter increases hemoglobin saturation in exacerbation of asthma.
Comment in
-
[Inhaled budesonide for acute asthma--is it all a question of time and space?].J Pediatr (Rio J). 2004 Mar-Apr;80(2):88-9. J Pediatr (Rio J). 2004. PMID: 15079175 Portuguese. No abstract available.
Similar articles
-
Randomized, controlled trial of inhaled budesonide as an adjunct to oral prednisone in acute asthma.Acad Emerg Med. 1998 Mar;5(3):209-13. doi: 10.1111/j.1553-2712.1998.tb02614.x. Acad Emerg Med. 1998. PMID: 9523927 Clinical Trial.
-
Efficacy of nebulized budesonide compared to oral prednisolone in acute bronchial asthma.Acta Paediatr. 1999 Aug;88(8):835-40. doi: 10.1080/08035259950168748. Acta Paediatr. 1999. PMID: 10503681 Clinical Trial.
-
[The efficacy of nebulized budesonide in acute moderate to severe exacerbations of asthma in children].Zhonghua Jie He He Hu Xi Za Zhi. 2012 Apr;35(4):269-74. Zhonghua Jie He He Hu Xi Za Zhi. 2012. PMID: 22781199 Clinical Trial. Chinese.
-
Expert panel consensus recommendations on the utilization of nebulized budesonide for managing asthma and COPD in both stable and exacerbation stages in Thailand.J Asthma. 2024 Oct;61(10):1136-1151. doi: 10.1080/02770903.2024.2334897. Epub 2024 Apr 3. J Asthma. 2024. PMID: 38527278 Review.
-
Practical considerations of nebulized corticosteroid in children with acute asthmatic exacerbation: A consensus.Asian Pac J Allergy Immunol. 2021 Sep;39(3):168-176. doi: 10.12932/AP-170918-0407. Asian Pac J Allergy Immunol. 2021. PMID: 30660170 Review.
Cited by
-
Inhaled steroids for acute asthma following emergency department discharge.Cochrane Database Syst Rev. 2012 Dec 12;12(12):CD002316. doi: 10.1002/14651858.CD002316.pub2. Cochrane Database Syst Rev. 2012. PMID: 23235590 Free PMC article. Review.
-
Asthma and other recurrent wheezing disorders in children (acute).BMJ Clin Evid. 2012 Jul 6;2012:0300. BMJ Clin Evid. 2012. PMID: 24807832 Free PMC article. Review.
-
Early use of inhaled corticosteroids in the emergency department treatment of acute asthma.Cochrane Database Syst Rev. 2012 Dec 12;12(12):CD002308. doi: 10.1002/14651858.CD002308.pub2. Cochrane Database Syst Rev. 2012. PMID: 23235589 Free PMC article. Review.
-
Role of Inhaled Corticosteroids for Asthma Exacerbation in Children: An Updated Meta-Analysis.J Emerg Trauma Shock. 2020 Apr-Jun;13(2):161-166. doi: 10.4103/JETS.JETS_116_19. Epub 2020 Jun 10. J Emerg Trauma Shock. 2020. PMID: 33013097 Free PMC article.
-
Update on the utility of corticosteroids in acute pediatric respiratory disorders.Allergy Asthma Proc. 2015 Sep-Oct;36(5):332-8. doi: 10.2500/aap.2015.36.3865. Allergy Asthma Proc. 2015. PMID: 26314814 Free PMC article. Review.