Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Mar;6(2):126-30.
doi: 10.1007/s11883-004-0101-y.

Endothelial lipase and cholesterol metabolism

Mehmet Cilingiroglu  1 , Christie Ballantyne
Affiliations
Review

Endothelial lipase and cholesterol metabolism

Mehmet Cilingiroglu et al. Curr Atheroscler Rep. 2004 Mar.

Abstract

Endothelial lipase (EL), a new member of the lipase gene family, was recently cloned and has a significant role in plasma high-density lipoprotein levels (HDL). EL has a highly similar molecular homology to lipoprotein lipase and hepatic lipase. It is synthesized by endothelial cells and functions at the cell surface. EL primarily has phospholipase A1 activity. Animals that overexpress EL showed decreased HDL cholesterol levels and those that lack EL show elevated levels of HDL cholesterol. The expression is highly regulated by cytokines and physical forces. These data suggest that EL may play a significant role in atherosclerosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Clin Invest. 1993 Jul;92(1):411-7 - PubMed
    1. Curr Opin Lipidol. 2000 Apr;11(2):141-7 - PubMed
    1. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2748-53 - PubMed
    1. J Lipid Res. 2002 Jun;43(6):921-9 - PubMed
    1. Control Clin Trials. 1996 Dec;17(6):550-83 - PubMed

LinkOut - more resources