Review
doi: 10.1016/0168-9525(92)90329-3.
Mating-type gene switching in Saccharomyces cerevisiae
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- PMID: 1492369
- DOI: 10.1016/0168-9525(92)90329-3
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Review
Mating-type gene switching in Saccharomyces cerevisiae
Trends Genet.
1992 Dec.
Abstract
The study of yeast mating-type (MAT) gene switching has provided insights into several aspects of the regulation of gene expression. MAT switching is accomplished by a highly programmed site-specific homologous recombination event in which mating-type-specific sequences at MAT are replaced by alternative DNA sequences copied from one of two unexpressed donors. The mating-type system has also provided an opportunity to study both the genetic regulation of gene silencing by alterations in chromatin structure, and the basis of preferential recombination between a recipient of genetic information and one of several possible donors.
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