Quantitative aspects of the multiplication of influenza A virus in the mouse lung; relation between the degree of viral multiplication and the extent of pneumonia
- PMID: 14907966
- PMCID: PMC2212055
- DOI: 10.1084/jem.95.2.135
Quantitative aspects of the multiplication of influenza A virus in the mouse lung; relation between the degree of viral multiplication and the extent of pneumonia
Abstract
Influenza A virus, PR8 strain, increases in amount in the infected mouse lung at a relatively constant rate. When more than 25 M.S.50 doses of virus is inoculated, the rate of multiplication appears to be independent of the amount of virus introduced; has a value of 1,100-fold increase per day. The rate of increase in the pulmonary lesions induced by infection of the mouse lung with PR8 also appears to be relatively constant and independent of the amount of virus inoculated; has a value of 8.5-fold increase per day. The essential variables in the PR8-mouse lung system appear to be equated satisfactorily by functions which were derived previously (4) during a similar quantitative investigation on pneumonia virus of mice (PVM). Evidence in support of the hypothesis that the processes of multiplication of PR8 and PVM are different in the mouse lung is presented.
Similar articles
-
Effect of sodium monofluoroacetate on the multiplication of influenza viruses, mumps virus and pneumonia virus of mice (PVM).J Exp Med. 1952 Dec;96(6):531-48. doi: 10.1084/jem.96.6.531. J Exp Med. 1952. PMID: 13022848 Free PMC article.
-
The dependence of the pathological lesion upon the multiplication of pneumonia virus of mice (PVM); kinetic relation between the degree of viral multiplication and the extent of pneumonia.J Exp Med. 1951 Feb;93(2):139-50. doi: 10.1084/jem.93.2.139. J Exp Med. 1951. PMID: 14803638 Free PMC article.
-
Reproduction of influenza viruses; quantitative investigations with particle enumeration procedures on the dynamics of influenza A and B virus reproduction.J Exp Med. 1955 Oct 1;102(4):441-73. doi: 10.1084/jem.102.4.441. J Exp Med. 1955. PMID: 13263486 Free PMC article.
-
Antigenic variants of influenza A virus (PR8 strain). V. Virulence, antigenic potency, and cross-protection tests in mice of the original and second series.J Exp Med. 1958 Jun 1;107(6):857-68. doi: 10.1084/jem.107.6.857. J Exp Med. 1958. PMID: 13539310 Free PMC article.
-
Characteristics of the multiplication cycle of pneumonia virus of mice (PVM).J Exp Med. 1951 Feb;93(2):151-60. doi: 10.1084/jem.93.2.151. J Exp Med. 1951. PMID: 14803639 Free PMC article.
Cited by
-
Crossing the scale from within-host infection dynamics to between-host transmission fitness: a discussion of current assumptions and knowledge.Philos Trans R Soc Lond B Biol Sci. 2015 Aug 19;370(1675):20140302. doi: 10.1098/rstb.2014.0302. Philos Trans R Soc Lond B Biol Sci. 2015. PMID: 26150668 Free PMC article. Review.
-
Virus reproduction and virus disease.Can Med Assoc J. 1955 Nov 15;73(10):778-82. Can Med Assoc J. 1955. PMID: 13270168 Free PMC article. No abstract available.
-
Quantitative studies on influenza virus infection of the chick embryo by the amniotic route.J Bacteriol. 1956 May;71(5):505-15. doi: 10.1128/jb.71.5.505-515.1956. J Bacteriol. 1956. PMID: 13331861 Free PMC article. No abstract available.
-
Initial Inoculum and the Severity of COVID-19: A Mathematical Modeling Study of the Dose-Response of SARS-CoV-2 Infections.Epidemiologia (Basel). 2020 Oct 21;1(1):5-15. doi: 10.3390/epidemiologia1010003. Epidemiologia (Basel). 2020. PMID: 36417207 Free PMC article.
-
Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice.J Clin Invest. 1990 Mar;85(3):739-45. doi: 10.1172/JCI114499. J Clin Invest. 1990. PMID: 2155924 Free PMC article.
