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. 1978 Apr;5(4):1289-95.
doi: 10.1093/nar/5.4.1289.

Initiation of adenovirus DNA replication does not occur via a hairpin mechanism

J S Sussenbach, M G Kujik
Free PMC article

Initiation of adenovirus DNA replication does not occur via a hairpin mechanism

J S Sussenbach et al. Nucleic Acids Res. 1978 Apr.
Free PMC article

Abstract

Models have been proposed suggesting that initiation of adenovirus DNA replication might occur via a hairpin mechanism. A consequence of the models is a covalent linkage of progeny and parental DNA in newly completed molecules. Analysis of mature molecules from KB cells infected with adenovirus type 5 indicates that, if a hairpin mechanism is involved, the length of the hairpin must be shorter than 50 basepairs long. Recent nucleotide sequence analysis of the termini of adenovirus type 5 DNA (P.H. Steenbergh et al. (1977) Nucl. Acids Res. 4, 4371-4389) has shown that a hairpin of this size does not exist and that therefore a hairpin mechanism is unlikely.

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