Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives

doi:10.1007/s00384-003-0563-3

Review

. 2004 Sep;19(5):401-13.

doi: 10.1007/s00384-003-0563-3. Epub 2004 Jan 24.

Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives

Robert Grützmann¹, Hans Detlev Saeger, Jutta Lüttges, Hans Konrad Schackert, Holger Kalthoff, Günter Klöppel, Christian Pilarsky

Affiliations

Affiliation

¹ Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, Dresden, Germany. Robert.Gruetzmann@mailbox.tu-dresden.de

PMID: 14745573
DOI: 10.1007/s00384-003-0563-3

Review

Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives

Robert Grützmann et al. Int J Colorectal Dis. 2004 Sep.

. 2004 Sep;19(5):401-13.

doi: 10.1007/s00384-003-0563-3. Epub 2004 Jan 24.

Authors

Robert Grützmann¹, Hans Detlev Saeger, Jutta Lüttges, Hans Konrad Schackert, Holger Kalthoff, Günter Klöppel, Christian Pilarsky

Affiliation

¹ Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, Dresden, Germany. Robert.Gruetzmann@mailbox.tu-dresden.de

PMID: 14745573
DOI: 10.1007/s00384-003-0563-3

Abstract

Background: Pancreatic ductal adenocarcinoma has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and adjuvant and/or neoadjuvant treatment need to be identified. One of the key techniques that has been developed to achieve this goal is DNA microarray profiling, which is used to identify the mechanisms of deregulated molecular functions in pancreatic carcinoma cells.

Objective: As several studies using microarrays have already been published, this review attempts to compare published data and crossvalidate the results. In addition, the applied techniques are discussed.

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References

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[1] Ann Surg. 2001 Dec;234(6):769-78; discussion 778-9 - PubMed

[2] Ann Surg. 2001 Dec;234(6):769-78; discussion 778-9 - PubMed

[3] Oncogene. 2002 Jan 17;21(3):475-8 - PubMed

[4] Oncogene. 2002 Jan 17;21(3):475-8 - PubMed

[5] Int J Pancreatol. 1992 Feb;11(1):43-7 - PubMed

[6] Int J Pancreatol. 1992 Feb;11(1):43-7 - PubMed

[7] Genome Res. 1996 Jul;6(7):639-45 - PubMed

[8] Genome Res. 1996 Jul;6(7):639-45 - PubMed

[9] Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6745-50 - PubMed

[10] Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6745-50 - PubMed

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Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives

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Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives

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