Review
doi: 10.1016/j.ejca.2003.09.027.
RNA polymerase III transcription--a battleground for tumour suppressors and oncogenes
Affiliations
- PMID: 14687785
- DOI: 10.1016/j.ejca.2003.09.027
Item in Clipboard
Review
RNA polymerase III transcription--a battleground for tumour suppressors and oncogenes
Eur J Cancer.
2004 Jan.
Abstract
This review provides a summary of the European Association for Cancer Research Award Lecture, presented at the ECCO12 meeting in Copenhagen in September 2003. It describes what we have learnt about the mechanisms responsible for deregulating RNA polymerase III transcription in transformed cells. A network has been discovered of unanticipated links to key tumour suppressors and oncogenes. Novel functions have been revealed for RB, p53 and c-Myc, that may help explain their profound biological effects.
Similar articles
-
RNA polymerase III transcription and cancer.Oncogene. 2004 Apr 19;23(18):3208-16. doi: 10.1038/sj.onc.1207547. Oncogene. 2004. PMID: 15094770 Review.
-
RNA polymerase III transcription: its control by tumor suppressors and its deregulation by transforming agents.Gene Expr. 2000;9(1-2):15-28. doi: 10.3727/000000001783992713. Gene Expr. 2000. PMID: 11097422 Free PMC article. Review.
-
Direct regulation of RNA polymerase III transcription by RB, p53 and c-Myc.Cell Cycle. 2003 May-Jun;2(3):181-4. Cell Cycle. 2003. PMID: 12734418 Review.
-
Distinct mechanisms for repression of RNA polymerase III transcription by the retinoblastoma tumor suppressor protein.Mol Cell Biol. 2004 Jul;24(13):5989-99. doi: 10.1128/MCB.24.13.5989-5999.2004. Mol Cell Biol. 2004. PMID: 15199152 Free PMC article.
-
Transcription by RNA polymerases I and III: a potential link between cell growth, protein synthesis and the retinoblastoma protein.J Mol Med (Berl). 1998 Feb;76(2):94-103. doi: 10.1007/s001090050196. J Mol Med (Berl). 1998. PMID: 9500674 Review.
Cited by
-
RNA polymerase III transcription in cancer: the BRF2 connection.Mol Cancer. 2011 Apr 25;10:47. doi: 10.1186/1476-4598-10-47. Mol Cancer. 2011. PMID: 21518452 Free PMC article. Review.
-
Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development.PLoS Biol. 2007 Nov;5(11):e312. doi: 10.1371/journal.pbio.0050312. PLoS Biol. 2007. PMID: 18044988 Free PMC article.
-
APOMAB, a La-specific monoclonal antibody, detects the apoptotic tumor response to life-prolonging and DNA-damaging chemotherapy.PLoS One. 2009;4(2):e4558. doi: 10.1371/journal.pone.0004558. Epub 2009 Feb 27. PLoS One. 2009. PMID: 19247492 Free PMC article.
-
Human Maf1 negatively regulates RNA polymerase III transcription via the TFIIB family members Brf1 and Brf2.Int J Biol Sci. 2007 May 1;3(5):292-302. doi: 10.7150/ijbs.3.292. Int J Biol Sci. 2007. PMID: 17505538 Free PMC article.
-
Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes.Nucleic Acids Res. 2006 Jan 10;34(1):286-94. doi: 10.1093/nar/gkj402. Print 2006. Nucleic Acids Res. 2006. PMID: 16407335 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
