Immunomodulatory effects of fetal and adult mesenchymal stem cells
- PMID: 14660044
- DOI: 10.1080/14653240310003611
Immunomodulatory effects of fetal and adult mesenchymal stem cells
Abstract
Mesenchymal stem cells (MSC) derived from adult BM or fetal liver form several mesenchymal tissues after appropriate stimulation. Reports indicate that MSC have unique immunologic properties, making them ideal for cellular therapy. MSC are not immunogenic, they do not stimulate alloreactivity, and they escape lysis by cytotoxic T-cells and natural killer (NK)-cells. Thus, MSC may be transplantable between HLA-mismatched individuals without the need for host immunosuppression. Furthermore, adult MSC appear to be immunosuppressive as they reduce alloreactivity and the formation of cytotoxic lymphocytes in vitro. In vivo, adult MSC prolong the time to rejection of mis-matched skin grafts in baboons. The immunosuppressive properties of first trimester fetal MSC are less pronounced, but inducible with IFNgamma. These findings imply a potential role for MSC, not only in the repair of damaged tissues, but also in the manipulation of immune responses.
Similar articles
-
The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function.Cell Immunol. 2008 Feb;251(2):131-6. doi: 10.1016/j.cellimm.2008.04.009. Epub 2008 May 27. Cell Immunol. 2008. PMID: 18502411
-
Mesenchymal stromal cells: Tissue repair and immune modulation.Cytotherapy. 2006;8(6):559-61. doi: 10.1080/14653240601045399. Cytotherapy. 2006. PMID: 17148032 Review.
-
Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G.Transplantation. 2007 Jul 27;84(2):231-7. doi: 10.1097/01.tp.0000267918.07906.08. Transplantation. 2007. PMID: 17667815
-
HLA-G is a crucial immunosuppressive molecule secreted by adult human mesenchymal stem cells.Transplantation. 2009 May 15;87(9 Suppl):S62-6. doi: 10.1097/TP.0b013e3181a2a4b3. Transplantation. 2009. PMID: 19424010
-
Immunoregulatory function of mesenchymal stem cells.Eur J Immunol. 2006 Oct;36(10):2566-73. doi: 10.1002/eji.200636416. Eur J Immunol. 2006. PMID: 17013987 Review.
Cited by
-
Stem cells for the treatment of musculoskeletal pain.World J Stem Cells. 2015 Jan 26;7(1):96-105. doi: 10.4252/wjsc.v7.i1.96. World J Stem Cells. 2015. PMID: 25621109 Free PMC article. Review.
-
Stem cell therapy in pain medicine.Korean J Pain. 2019 Oct 1;32(4):245-255. doi: 10.3344/kjp.2019.32.4.245. Korean J Pain. 2019. PMID: 31569916 Free PMC article. Review.
-
Immunoregulatory impact of human mesenchymal-conditioned media and mesenchymal derived exosomes on monocytes.Mol Biol Res Commun. 2019 Jun;8(2):79-89. doi: 10.22099/mbrc.2019.33346.1397. Mol Biol Res Commun. 2019. PMID: 31531379 Free PMC article.
-
Neuroprotective properties of marrow-isolated adult multilineage-inducible cells in rat hippocampus following global cerebral ischemia are enhanced when complexed to biomimetic microcarriers.J Neurochem. 2011 Dec;119(5):972-88. doi: 10.1111/j.1471-4159.2011.07272.x. Epub 2011 May 13. J Neurochem. 2011. PMID: 21496021 Free PMC article.
-
Stem cell therapy to protect and repair the developing brain: a review of mechanisms of action of cord blood and amnion epithelial derived cells.Front Neurosci. 2013 Oct 24;7:194. doi: 10.3389/fnins.2013.00194. Front Neurosci. 2013. PMID: 24167471 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials