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. 2003 Nov 28;302(5650):1563-6.
doi: 10.1126/science.1087641.

Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12

Xiaochen Wang  1 , Yi-Chun Wu, Valerie A Fadok, Ming-Chia Lee, Keiko Gengyo-Ando, Li-Chun Cheng, Duncan Ledwich, Pei-Ken Hsu, Jia-Yun Chen, Bin-Kuan Chou, Peter Henson, Shohei Mitani, Ding Xue
Affiliations

Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12

Xiaochen Wang et al. Science. .

Abstract

During apoptosis, phosphatidylserine, which is normally restricted to the inner leaflet of the plasma membrane, is exposed on the surface of apoptotic cells and has been suggested to act as an "eat-me" signal to trigger phagocytosis. It is unclear how phagocytes recognize phosphatidylserine. Recently, a putative phosphatidylserine receptor (PSR) was identified and proposed to mediate recognition of phosphatidylserine and phagocytosis. We report that psr-1, the Caenorhabditis elegans homolog of PSR, is important for cell corpse engulfment. In vitro PSR-1 binds preferentially phosphatidylserine or cells with exposed phosphatidylserine. In C. elegans, PSR-1 acts in the same cell corpse engulfment pathway mediated by intracellular signaling molecules CED-2 (homologous to the human CrkII protein), CED-5 (DOCK180), CED-10 (Rac GTPase), and CED-12 (ELMO), possibly through direct interaction with CED-5 and CED-12. Our findings suggest that PSR-1 is likely an upstream receptor for the signaling pathway containing CED-2, CED-5, CED-10, and CED-12 proteins and plays an important role in recognizing phosphatidylserine during phagocytosis.

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  • Cell biology. Eat me or die.
    Savill J, Gregory C, Haslett C. Savill J, et al. Science. 2003 Nov 28;302(5650):1516-7. doi: 10.1126/science.1092533. Science. 2003. PMID: 14645835 No abstract available.

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