Vacuolar H+ pumping ATPases in luminal acidic organelles and extracellular compartments: common rotational mechanism and diverse physiological roles

doi:10.1023/a:1025780932403

Review

. 2003 Aug;35(4):347-58.

doi: 10.1023/a:1025780932403.

Vacuolar H+ pumping ATPases in luminal acidic organelles and extracellular compartments: common rotational mechanism and diverse physiological roles

Ge-Hong Sun-Wada¹, Yoh Wada, Masamitsu Futai

Affiliations

Affiliation

¹ Division of Biological Sciences and Nanoscience, and Nanotechnology Center, Japan Science and Technology Cooperation, Institute of Scientific and Industrial Research, Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan.

PMID: 14635780
DOI: 10.1023/a:1025780932403

Review

Vacuolar H+ pumping ATPases in luminal acidic organelles and extracellular compartments: common rotational mechanism and diverse physiological roles

Ge-Hong Sun-Wada et al. J Bioenerg Biomembr. 2003 Aug.

. 2003 Aug;35(4):347-58.

doi: 10.1023/a:1025780932403.

Authors

Ge-Hong Sun-Wada¹, Yoh Wada, Masamitsu Futai

Affiliation

¹ Division of Biological Sciences and Nanoscience, and Nanotechnology Center, Japan Science and Technology Cooperation, Institute of Scientific and Industrial Research, Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan.

PMID: 14635780
DOI: 10.1023/a:1025780932403

Abstract

Cytoplasmic organelles with an acidic luminal pH include vacuoles, coated vesicles, lysosomes, the Golgi apparatus, and synaptic vesicles. Acidic compartments are also known outside specialized cells such as osteoclasts. The unique acidic pH is formed by V-ATPase (Vacuolar type ATPase), other ion transporters, and the buffering action of proteins inside the organelles. V-ATPase hydrolyzes ATP and transports protons inside an organelle or extracellular compartment. We have summarized recent progress on mouse V-ATPases and their varying localizations together with their mechanism emphasizing similarities with F-type ATPases.

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References

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1. J Biol Chem. 2003 Jun 27;278(26):23714-9 - PubMed
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1. Physiol Rev. 1999 Apr;79(2):361-85 - PubMed
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[1] Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13448-52 - PubMed

[2] Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13448-52 - PubMed

[3] J Biol Chem. 2003 Jun 27;278(26):23714-9 - PubMed

[4] J Biol Chem. 2003 Jun 27;278(26):23714-9 - PubMed

[5] J Biol Chem. 2000 Mar 3;275(9):6515-22 - PubMed

[6] J Biol Chem. 2000 Mar 3;275(9):6515-22 - PubMed

[7] Physiol Rev. 1999 Apr;79(2):361-85 - PubMed

[8] Physiol Rev. 1999 Apr;79(2):361-85 - PubMed

[9] J Exp Biol. 2000 Jan;203(Pt 1):9-17 - PubMed

[10] J Exp Biol. 2000 Jan;203(Pt 1):9-17 - PubMed

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Vacuolar H+ pumping ATPases in luminal acidic organelles and extracellular compartments: common rotational mechanism and diverse physiological roles

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Vacuolar H+ pumping ATPases in luminal acidic organelles and extracellular compartments: common rotational mechanism and diverse physiological roles

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