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. 2003 Dec;9(12):1528-32.
doi: 10.1038/nm959. Epub 2003 Nov 16.

Contribution of hematopoietic stem cells to skeletal muscle

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Contribution of hematopoietic stem cells to skeletal muscle

Stéphane Y Corbel et al. Nat Med. 2003 Dec.

Abstract

Cells from adult bone marrow participate in the regeneration of damaged skeletal myofibers. However, the relationship of these cells with the various hematopoietic and nonhematopoietic cell types found in bone marrow is still unclear. Here we show that the progeny of a single cell can both reconstitute the hematopoietic system and contribute to muscle regeneration. Integration of bone marrow cells into myofibers occurs spontaneously at low frequency and increases with muscle damage. Thus, classically defined single hematopoietic stem cells can give rise to both blood and muscle.

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