Contribution of hematopoietic stem cells to skeletal muscle
- PMID: 14625543
- DOI: 10.1038/nm959
Contribution of hematopoietic stem cells to skeletal muscle
Abstract
Cells from adult bone marrow participate in the regeneration of damaged skeletal myofibers. However, the relationship of these cells with the various hematopoietic and nonhematopoietic cell types found in bone marrow is still unclear. Here we show that the progeny of a single cell can both reconstitute the hematopoietic system and contribute to muscle regeneration. Integration of bone marrow cells into myofibers occurs spontaneously at low frequency and increases with muscle damage. Thus, classically defined single hematopoietic stem cells can give rise to both blood and muscle.
Comment in
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Marrow to muscle, fission versus fusion.Nat Med. 2003 Dec;9(12):1461-2. doi: 10.1038/nm1203-1461. Nat Med. 2003. PMID: 14647520 No abstract available.
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