Downstream of guidance receptors: entering the baroque period of axon guidance signaling
- PMID: 14527427
- DOI: 10.1016/s0896-6273(03)00603-2
Downstream of guidance receptors: entering the baroque period of axon guidance signaling
Abstract
The Roundabout ("Robo") family of transmembrane proteins are the receptors and mediators of the repellent axon guidance signal Slit. However, the molecular mechanisms by which Robo signaling leads to growth cone or neuron repulsion are still poorly understood. A study by Fan et al. in this issue of Neuron expands the repertoire of Robo pathway components and stimulates a new look at axon guidance signaling in general.
Comment on
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Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline.Neuron. 2003 Sep 25;40(1):113-27. doi: 10.1016/s0896-6273(03)00591-9. Neuron. 2003. PMID: 14527437
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