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. 1961;25(1):41-8.

The use of vaccinia hyperimmune gamma-globulin in the prophylaxis of smallpox

C H KEMPE, C BOWLES, G MEIKLEJOHN, T O BERGE, L ST VINCENT, B V BABU, S GOVINDARAJAN, N R RATNAKANNAN, A W DOWNIE, V R MURTHY

The use of vaccinia hyperimmune gamma-globulin in the prophylaxis of smallpox

C H KEMPE et al. Bull World Health Organ. 1961.

Abstract

This paper records an attempt to assess the prophylactic value of immune gamma-globulin, prepared from the serum of recently vaccinated adults, in the protection of close contacts of smallpox in Madras. The results serve to confirm findings of a previous study made in Madras in 1953, and show that the incidence of smallpox in close contacts given immune gamma-globulin prophylactically was about a quarter of that in the control contacts who received no such passive immunization-a statistically significant difference. Because of the limited supply of immune gamma-globulin, it is likely that its prophylactic use will be restricted to those especially at risk, for example, close unvaccinated family contacts, newborn infants and pregnant women.

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References

    1. Pediatrics. 1956 Aug;18(2):177-88 - PubMed
    1. Pediatrics. 1960 Aug;26:176-89 - PubMed

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