A positive regulator of the ribosomal protein gene, beta factor, belongs to the ETS oncoprotein family

doi:10.1042/bj2870349

Comparative Study

. 1992 Oct 15;287 ( Pt 2)(Pt 2):349-53.

doi: 10.1042/bj2870349.

A positive regulator of the ribosomal protein gene, beta factor, belongs to the ETS oncoprotein family

T Yoganathan¹, N K Bhat, B H Sells

Affiliations

PMID: 1445193
PMCID: PMC1133171
DOI: 10.1042/bj2870349

Comparative Study

A positive regulator of the ribosomal protein gene, beta factor, belongs to the ETS oncoprotein family

T Yoganathan et al. Biochem J. 1992.

. 1992 Oct 15;287 ( Pt 2)(Pt 2):349-53.

doi: 10.1042/bj2870349.

Authors

T Yoganathan¹, N K Bhat, B H Sells

Affiliation

¹ Department of Molecular Biology and Genetics, College of Biological Science, University of Guelph, Ontario, Canada.

PMID: 1445193
PMCID: PMC1133171
DOI: 10.1042/bj2870349

Abstract

The beta factor, which interacts with the rpL32 promoter, binds to the sequence 5'-GAGCCGGAAGTG and trans-activates this gene. Comparison of the DNA sequences bound by the beta factor with those bound by other known DNA-binding proteins revealed that the ETS proteins interact with similar DNA sequences. Consequently we have examined the relationship of the beta factor to the several ETS proteins so far reported. Antibody and oligonucleotide competition experiments, performed by using electrophoretic shift analysis, revealed that the beta factor contains ETS epitopes and that it is immunologically related to both of the GA-binding proteins (GABPs), implying that the beta factor may consist of two separate protein subunits.

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[1] EMBO J. 1985 Dec 16;4(13A):3483-8 - PubMed

[2] EMBO J. 1985 Dec 16;4(13A):3483-8 - PubMed

[3] Mol Cell Biol. 1986 Aug;6(8):2774-83 - PubMed

[4] Mol Cell Biol. 1986 Aug;6(8):2774-83 - PubMed

[5] Proc Natl Acad Sci U S A. 1983 Jul;80(14):4403-7 - PubMed

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[10] Nature. 1983 Nov 24-30;306(5941):395-7 - PubMed

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A positive regulator of the ribosomal protein gene, beta factor, belongs to the ETS oncoprotein family

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A positive regulator of the ribosomal protein gene, beta factor, belongs to the ETS oncoprotein family

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