Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1992 Oct 1;89(19):8859-63.
doi: 10.1073/pnas.89.19.8859.

Molecular cloning and characterization of additional factors that bind to the interferon-alpha/beta response element B of the murine (2'-5')oligoadenylate synthetase ME-12 gene

C Yan  1 , I Tamm
Affiliations
Comparative Study

Molecular cloning and characterization of additional factors that bind to the interferon-alpha/beta response element B of the murine (2'-5')oligoadenylate synthetase ME-12 gene

C Yan et al. Proc Natl Acad Sci U S A. .

Abstract

The function of interferon (IFN) response elements (IREs) may be classified into two classes according to the location of the IRE in the polymerase II transcription promoter: located upstream of the core promoter, or located within the core promoter. Thus, the IRE-binding factors (IREBFs) can serve as sequence-specific transcription factors that activate IFN-inducible gene transcription and they can participate in preinitiation complex formation. In the murine and human (2'-5')oligoadenylate synthetase genes the IRE is located within the core promoter region. For this reason, it is important to isolate cDNAs encoding protein factors that can bind to this IRE and determine their functional roles in the regulation of expression of the IFN-inducible (2'-5')oligoadenylate synthetase gene. We have isolated three groups of cDNAs that encode IREBFs. Here we report on clone 38 cDNA, which contains an open reading frame encoding a protein of 277 amino acids that is designated IREBF-2. The C terminus of IREBF-2 is extremely proline-rich and contains a high percentage of short-armed amino acids. IREBF-2 shares marked similarity with some gene products of the herpes group of viruses. These gene products are potent transcription activators. IREBF-2 is constitutively expressed in BALB/c 3T3 cells.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Mol Cell Biol. 1989 Jan;9(1):342-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Nov;85(22):8521-5 - PubMed
    1. Science. 1989 Jul 28;245(4916):371-8 - PubMed
    1. Gene. 1988 Dec 20;73(2):499-507 - PubMed
    1. Genes Dev. 1988 Dec;2(12A):1557-69 - PubMed

Publication types

MeSH terms

LinkOut - more resources