Differential effects of cyclosporine and etretinate on serum cytokine levels in patients with psoriasis
- PMID: 1401309
- DOI: 10.1016/0190-9622(92)70224-4
Differential effects of cyclosporine and etretinate on serum cytokine levels in patients with psoriasis
Abstract
Background: The in vivo effects of cyclosporine and etretinate on the immune system are still unclear.
Objective: Our purpose was to determine the effects of these drugs on in vivo production of various cytokines.
Methods: Serum cytokine levels were measured sequentially by radioimmunoassay in psoriasis patients treated with either cyclosporine or etretinate.
Results: Interferon-gamma levels were initially elevated and rapidly returned to baseline levels before clinical improvement in both treatment groups. A transient increase before the relapse was also observed in some patients. Etretinate treatment resulted in a substantial decrease in tumor necrosis factor-alpha levels, whereas an unpredictable increase was found during the late phase of cyclosporine treatment.
Conclusion: The in vivo effects of antipsoriatic drugs on cytokine production are different from those demonstrated in vitro. Measurement of serum cytokine levels is useful for monitoring patients with psoriasis.
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