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. 1992 Apr;53(4):466-71.

Characterization of a feline T-cell-specific monoclonal antibody reactive with a CD5-like molecule

C D Ackley  1 , M D Cooper
Affiliations
  • PMID: 1375007

Characterization of a feline T-cell-specific monoclonal antibody reactive with a CD5-like molecule

C D Ackley et al. Am J Vet Res. 1992 Apr.

Abstract

The 43 monoclonal antibody raised against feline T cells was found to react with a single-chain glycoprotein of Mr 72,000 that is present on most thymocytes, 60% of lymph node cells, 20% of splenocytes, and 45% of blood mononuclear cells. All CD4+ and CD8+ T cells were found to express the 43-reactive determinant, as did a small subpopulation of CD4-/CD8-/IgM- lymphocytes in the periphery. The 43-reactive determinant was not detected on B cells, macrophages, or other types of blood cells. The 43 antigen was phosphorylated in resting and activated T cells. Its expression was upregulated by stimulation with phorbol myristate acetate and with phytohemagglutinin. When added to concanavalin A-stimulated T-cell cultures in low concentrations, the 43 antibody was found to augment mitogenesis. The data indicate that this antibody may identify a CD5 homologue on feline T cells.

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