Review
doi: 10.1016/0168-9525(92)90219-t.
X-chromosome inactivation and cell memory
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- PMID: 1369742
- DOI: 10.1016/0168-9525(92)90219-t
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Review
X-chromosome inactivation and cell memory
Trends Genet.
1992 May.
Abstract
Mammalian X-chromosome inactivation is an excellent example of the faithful maintenance of a determined chromosomal state. As such, it may provide insight into the mechanisms for cell memory, defined as the faithful maintenance of a determined state in clonally derived progeny cells. We review here the aspects of X-chromosome inactivation that are relevant to cell memory and discuss the various molecular mechanisms that have been proposed to explain its occurrence, with emphasis on DNA methylation and a recently proposed mechanism that depends on the timing of replication.
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