Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Oct;388(5):331-8.
doi: 10.1007/s00423-003-0405-3. Epub 2003 Sep 10.

Influence of haemorrhagic shock on fracture healing

Mark Bumann  1 , Thomas Henke, Heinz Gerngross, Lutz Claes, Peter Augat
Affiliations

Influence of haemorrhagic shock on fracture healing

Mark Bumann et al. Langenbecks Arch Surg. 2003 Oct.

Abstract

Background: The purpose of the study was to evaluate the effect of haemorrhagic shock on the outcome of fracture healing.

Material and methods: Forty-two male Wistar rats were randomly divided into a control group and a shock group. After producing a tibia fracture we induced shock by creating a blood loss of 12 ml/kg body weight. The rats were isovolumetrically resuscitated with a colloid volume solution. Blood flow was measured by laser Doppler flowmetry. Mechanical properties were tested by three-point bending after 4 weeks.

Results: The blood flow of the shock group was characterised by no reduction in the distal region and in the soft tissue in the first 24 h, while the flow in the control group was reduced to 39% of the pre-fracture level. Biomechanical testing showed a better fracture healing outcome for the shock group than for the control group in failure load (31/11 N; P=0.06) and flexural rigidity (22,7/4,7 Nmm2; P=0.07).

Conclusions: In the shock group the restoration of vascularity in the distal region and in the soft tissue in the early healing stages, provoked by the isovolumic resuscitation, led to enhanced fracture healing. In addition, the results indicate that a fast blood supply may generate an improved initial healing process that results in an increased mechanical outcome of bone healing. In general, our findings underline the close interrelation between blood supply and successful fracture healing.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Clin Orthop Relat Res. 1998 Oct;(355 Suppl):S230-8 - PubMed
    1. Acta Orthop Scand. 1993 Apr;64(2):203-6 - PubMed
    1. Ann Plast Surg. 1997 Jun;38(6):623-31 - PubMed
    1. J Bone Joint Surg Br. 1985 Aug;67(4):650-5 - PubMed
    1. J Bone Joint Surg Br. 1990 Sep;72(5):822-9 - PubMed

LinkOut - more resources