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. 1992 Nov 19;360(6401):225-31.
doi: 10.1038/360225a0.

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

P Mombaerts  1 , A R Clarke, M A Rudnicki, J Iacomini, S Itohara, J J Lafaille, L Wang, Y Ichikawa, R Jaenisch, M L Hooper, et al.
Affiliations

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

P Mombaerts et al. Nature. .

Erratum in

  • Nature 1992 Dec 3;360(6403):491

Abstract

Analysis of mice carrying mutant T-cell antigen receptor (TCR) genes indicates that TCR-beta gene rearrangement or expression is critical for the differentiation of CD4-CD8- thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-alpha is irrelevant in these developmental processes. The development of gamma delta T cells does not depend on either TCR-alpha or TCR-beta.

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