Induction of CD13 expression on fresh myeloid leukaemia: correlation of CD13 expression with aminopeptidase-N activity
- PMID: 1353131
- DOI: 10.1016/0145-2126(92)90012-v
Induction of CD13 expression on fresh myeloid leukaemia: correlation of CD13 expression with aminopeptidase-N activity
Abstract
CD13 has proved to be a useful cell surface marker for depicting haematopoietic cells of the myeloid and monocytic lineages. Sequence data has shown CD13 to bear strong homology to Aminopeptidase-N. Expression of this antigen on myeloid leukaemic cells is, however, variable. We have looked at the effects of a phorbol ester PMA and a haematopoietic growth factor GM-CSF on the expression of CD13 displayed by a selected group of myeloid leukaemias at presentation and by normal peripheral blood granulocytes. We have found that PMA but not GM-CSF was able to stimulate CD13 expression on fresh myeloid leukaemic cells but granulocytes were stimulated by either PMA or GM-CSF. In addition, we have correlated CD13 expression with Aminopeptidase-N enzyme activity on fresh myeloid leukaemic cells. These results suggest that CD13 is functionally active on leukaemic cells and normal granulocytes.
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