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. 1992 Apr;12(4):1592-604.
doi: 10.1128/mcb.12.4.1592-1604.1992.

Expression of the CD4 gene requires a Myb transcription factor

G Siu  1 , A L Wurster, J S Lipsick, S M Hedrick
Affiliations

Expression of the CD4 gene requires a Myb transcription factor

G Siu et al. Mol Cell Biol. 1992 Apr.

Abstract

We have analyzed the control of developmental expression of the CD4 gene, which encodes an important recognition molecule and differentiation antigen on T cells. We have determined that the CD4 promoter alone functions at high levels in the CD4+ CD8- mature T cell but not at the early CD4+ CD8+ stage of T-cell development. In addition, the CD4 promoter functions only in T lymphocytes; thus, the stage and tissue specificity of the CD4 gene is mediated in part by its promoter. We have determined that a Myb transcription factor binds to the CD4 promoter and is critical for full promoter function. Thus, Myb plays an important role in the expression of T-cell-specific developmentally regulated genes.

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