Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus
- PMID: 1346257
- DOI: 10.1016/0092-8674(92)90206-r
Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus
Erratum in
- Cell 1992 Mar 6;68(5):following 994
Abstract
The attachment of erythrocytes infected with P. falciparum to human venular endothelium is the primary step leading to complications from severe and cerebral malaria. Intercellular adhesion molecule-1 (ICAM-1, CD54) has been implicated as a cytoadhesion receptor for P. falciparum-infected erythrocytes. Characterization of domain deletion, human/murine chimeric ICAM-1 molecules, and amino acid substitution mutants localized the primary binding site for parasitized erythrocytes to the first amino-terminal immunoglobulin-like domain of ICAM-1. The ICAM-1 binding site is distinct from those recognized by LFA-1, Mac-1, and the human major-type rhinoviruses. Synthetic peptides encompassing the binding site on ICAM-1 inhibited malaria-infected erythrocyte adhesion to ICAM-1-coated surfaces with a Ki of 0.1-0.3 mM, whereas the Ki for soluble ICAM-1 is 0.15 microM. These findings have implications for the therapeutic reversal of malaria-infected erythrocyte sequestration in the host microvasculature.
Similar articles
-
The binding site on ICAM-1 for Plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1-binding site.Cell. 1992 Jan 10;68(1):71-81. doi: 10.1016/0092-8674(92)90207-s. Cell. 1992. PMID: 1370656
-
The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus.Cell. 1990 Apr 20;61(2):243-54. doi: 10.1016/0092-8674(90)90805-o. Cell. 1990. PMID: 1970514
-
Dissection of the role of PfEMP1 and ICAM-1 in the sensing of Plasmodium-falciparum-infected erythrocytes by natural killer cells.PLoS One. 2007 Feb 21;2(2):e228. doi: 10.1371/journal.pone.0000228. PLoS One. 2007. PMID: 17311092 Free PMC article.
-
The role of ICAM-1 as a receptor for rhinovirus and malaria.Chem Immunol. 1991;50:116-34. Chem Immunol. 1991. PMID: 1686174 Review. No abstract available.
-
Host receptors for malaria-infected erythrocytes.Am J Trop Med Hyg. 1990 Aug;43(2 Pt 2):6-14. doi: 10.4269/ajtmh.1990.43.6. Am J Trop Med Hyg. 1990. PMID: 1697144 Review.
Cited by
-
Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1.J Exp Med. 1992 Oct 1;176(4):1183-9. doi: 10.1084/jem.176.4.1183. J Exp Med. 1992. PMID: 1383378 Free PMC article.
-
Interplay of Plasmodium falciparum and thrombin in brain endothelial barrier disruption.Sci Rep. 2019 Sep 11;9(1):13142. doi: 10.1038/s41598-019-49530-1. Sci Rep. 2019. PMID: 31511575 Free PMC article.
-
Interaction between Endothelial Protein C Receptor and Intercellular Adhesion Molecule 1 to Mediate Binding of Plasmodium falciparum-Infected Erythrocytes to Endothelial Cells.mBio. 2016 Jul 12;7(4):e00615-16. doi: 10.1128/mBio.00615-16. mBio. 2016. PMID: 27406562 Free PMC article.
-
An external sensing system in Plasmodium falciparum-infected erythrocytes.Malar J. 2016 Feb 19;15:103. doi: 10.1186/s12936-016-1144-6. Malar J. 2016. PMID: 26893139 Free PMC article.
-
Biophysical Tools and Concepts Enable Understanding of Asexual Blood Stage Malaria.Front Cell Infect Microbiol. 2022 May 31;12:908241. doi: 10.3389/fcimb.2022.908241. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35711656 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
