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. 1992 Dec;66(12):7452-60.
doi: 10.1128/JVI.66.12.7452-7460.1992.

Repression of liver-specific hepatitis B virus enhancer 2 activity by adenovirus E1A proteins

S T Chen  1 , H Su, J K Yee
Affiliations

Repression of liver-specific hepatitis B virus enhancer 2 activity by adenovirus E1A proteins

S T Chen et al. J Virol. 1992 Dec.

Abstract

Two regions of the hepatitis B virus (HBV) genome have been shown to display properties of a transcriptional enhancer. Enhancer 1 is active in most hepatoma lines examined as well as in some non-hepatocyte-derived cell lines. In contrast, enhancer 2 activity is strictly liver specific. In this study, we show that adenovirus E1A expression in the highly differentiated human hepatoma line Huh6 strongly inhibits HBV enhancer 2-stimulated transcription while having no effect on HBV enhancer 1 activity. A sequence motif in HBV enhancer 2 which is essential for its enhancer function is the target for E1A-mediated repression. The repression of HBV enhancer 2 activity is mediated through the N-terminal region of the E1A proteins known to bind a 300-kDa cellular protein. Our results suggest that HBV enhancer function may be modulated by a cellular mechanism similar to E1A-mediated transcriptional repression.

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