Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Jul;66(7):4452-6.
doi: 10.1128/JVI.66.7.4452-4456.1992.

The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID

C Hagemeier  1 , S Walker, R Caswell, T Kouzarides, J Sinclair
Affiliations

The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID

C Hagemeier et al. J Virol. 1992 Jul.

Abstract

We have asked how the human cytomegalovirus major immediate-early 1 (IE1) and 2 (IE2) proteins act to transactivate heterologous cellular and viral promoters. Here we show that transactivation of the human immunodeficiency virus long terminal repeat and the 70,000-molecular-weight heat shock protein (hsp70) promoter by IE1 is TATA box independent and that the IE1 protein does not interact directly with the TATA box-binding factor TFIID. Conversely, transactivation of these promoters by IE2 is TATA box dependent and a direct interaction between IE2 and TFIID occurs, suggesting that IE2 transactivation is mediated through interaction with TFIID.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Virus Res. 1985 Mar;2(2):107-21 - PubMed
    1. J Virol. 1988 Apr;62(4):1167-79 - PubMed
    1. Nature. 1986 Oct 2-8;323(6087):455-8 - PubMed
    1. Nature. 1988 Oct 6;335(6190):563-4 - PubMed
    1. Nucleic Acids Res. 1988 Jan 11;16(1):369 - PubMed

Publication types

LinkOut - more resources