Review
doi: 10.1038/357375a0.
Proteolysis, proteasomes and antigen presentation
Collaborators,
Affiliations
- PMID: 1317508
- DOI: 10.1038/357375a0
Item in Clipboard
Review
Proteolysis, proteasomes and antigen presentation
Nature.
.
Abstract
Proteins presented to the immune system must first be cleaved to small peptides by intracellular proteinases. Proteasomes are proteolytic complexes that degrade cytosolic and nuclear proteins. These particles have been implicated in ATP-ubiquitin-dependent proteolysis and in the processing of intracellular antigens for cytolytic immune responses.
Similar articles
-
Catheptic processing of protein antigens: enzymic and molecular aspects.Semin Immunol. 1990 Jul;2(4):255-71. Semin Immunol. 1990. PMID: 1983339 Review.
-
Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes.Nature. 1993 Sep 16;365(6443):264-7. doi: 10.1038/365264a0. Nature. 1993. PMID: 8396732
-
Antigen processing by the proteasome.Nat Rev Mol Cell Biol. 2001 Mar;2(3):179-87. doi: 10.1038/35056572. Nat Rev Mol Cell Biol. 2001. PMID: 11265247 Review.
-
Interference of monoclonal antibodies with proteolysis of antigens in cellular and in acellular systems.Ann Ist Super Sanita. 1991;27(1):15-9. Ann Ist Super Sanita. 1991. PMID: 1958024 Review.
-
A group-specific inhibitor of lysosomal cysteine proteinases selectively inhibits both proteolytic degradation and presentation of the antigen dinitrophenyl-poly-L-lysine by guinea pig accessory cells to T cells.J Immunol. 1986 Jan;136(2):452-8. J Immunol. 1986. PMID: 3079785
Cited by
-
The proteasome and its role in the nervous system.Cell Chem Biol. 2021 Jul 15;28(7):903-917. doi: 10.1016/j.chembiol.2021.04.003. Epub 2021 Apr 26. Cell Chem Biol. 2021. PMID: 33905676 Free PMC article. Review.
-
Differentiation of large extracellular vesicles in oral fluid: Combined protocol of small force centrifugation and sedimentation pattern analysis.J Extracell Biol. 2024 Feb 14;3(2):e143. doi: 10.1002/jex2.143. eCollection 2024 Feb. J Extracell Biol. 2024. PMID: 38939901 Free PMC article.
-
Purification and Characterization of Two Functional Forms of Intracellular Protease PfpI from the Hyperthermophilic Archaeon Pyrococcus furiosus.Appl Environ Microbiol. 1997 Jan;63(1):289-95. doi: 10.1128/aem.63.1.289-295.1997. Appl Environ Microbiol. 1997. PMID: 16535492 Free PMC article.
-
Rate of neurite outgrowth in sympathetic neurons is highly resistant to suppression of protein synthesis: role of protein degradation/synthesis coupling.Neurosci Lett. 2007 Jan 3;411(1):52-5. doi: 10.1016/j.neulet.2006.10.045. Epub 2006 Nov 16. Neurosci Lett. 2007. PMID: 17112665 Free PMC article.
-
Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells.Mol Cell Biol. 2006 Aug;26(15):5663-74. doi: 10.1128/MCB.02095-05. Mol Cell Biol. 2006. PMID: 16847321 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
