Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992;122(1-2):207-14.
doi: 10.1007/BF01321129.

Latency and reactivation of a thymidine kinase-negative bovine herpesvirus 1 deletion mutant

C A Whetstone  1 , J M Miller, B S Seal, L J Bello, W C Lawrence
Affiliations

Latency and reactivation of a thymidine kinase-negative bovine herpesvirus 1 deletion mutant

C A Whetstone et al. Arch Virol. 1992.

Abstract

A bovine herpesvirus 1 (BHV 1) mutant variant with a deletion in the thymidine kinase (TK) gene was assessed for its ability to establish latency and be reactivated in cattle. After treatment with dexamethasone, reactivated TK- BHV 1 was isolated from one of four cattle that received virus by intravenous inoculation only, and from four of four cattle that received virus by intranasal, intravaginal, and intravenous inoculation. Results prove that TK- BHV 1 will establish latency and can be reactivated in the natural host.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Virol. 1990 Sep;64(9):4288-95 - PubMed
    1. J Virol. 1983 Jul;47(1):259-64 - PubMed
    1. J Clin Microbiol. 1983 Jan;17(1):122-7 - PubMed
    1. Arch Virol. 1989;106(3-4):261-79 - PubMed
    1. J Virol. 1989 Jun;63(6):2861-5 - PubMed

Publication types

LinkOut - more resources