Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Jan;12(1):386-93.
doi: 10.1128/mcb.12.1.386-393.1992.

A colony-stimulating factor 1 (CSF-1) receptor/platelet-derived growth factor-beta receptor gene fusion confers CSF-1 independence and tumorigenicity on a c-myc-immortalized monocyte cell line

M R Eccles  1 , F J King, M D Cole
Affiliations

A colony-stimulating factor 1 (CSF-1) receptor/platelet-derived growth factor-beta receptor gene fusion confers CSF-1 independence and tumorigenicity on a c-myc-immortalized monocyte cell line

M R Eccles et al. Mol Cell Biol. 1992 Jan.

Abstract

Monocytes and macrophages express the receptor for the hematopoietic growth factor colony-stimulating factor 1 (CSF-1) and require this factor for growth in culture. A murine monocyte tumor cell line that lacks the usual requirement for CSF-1 was isolated. On the basis of the similarity of the structures of the CSF-1 and platelet-derived growth factor (PDGF) receptors and because monocytes normally secrete PDGF, we analyzed the tumor cell line for anomalous expression of the PDGF-R beta gene. Two different cDNAs that each contain sequences corresponding to the complete coding sequence of PDGF-R beta fused (in frame) to the amino-terminal half of the CSF-1 receptor were isolated. Introduction of these PDGF-R beta-related cDNAs into two partially transformed, CSF-1-dependent monocyte cell lines resulted in autonomous growth and cell transformation. These monocyte cell lines exhibit a novel form of growth factor receptor activation that can lead to oncogenic growth in collaboration with the c-myc oncogene.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Mol Cell Biol. 1989 Mar;9(3):1336-41 - PubMed
    1. Biochim Biophys Acta. 1989 Jul 28;989(1):1-10 - PubMed
    1. Annu Rev Biochem. 1989;58:45-77 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Nov;86(21):8314-8 - PubMed
    1. Cell. 1988 Nov 18;55(4):655-61 - PubMed

Publication types

MeSH terms

Substances