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Review
. 2003 Oct;18(4):1257-66.
doi: 10.14670/HH-18.1257.

Alpha-synuclein: between synaptic function and dysfunction

G Di Rosa  1 , D Puzzo, A Sant'Angelo, F Trinchese, O Arancio
Affiliations
Review

Alpha-synuclein: between synaptic function and dysfunction

G Di Rosa et al. Histol Histopathol. 2003 Oct.

Abstract

Alpha-synuclein belongs to a family of vertebrate proteins, encoded by three different genes: alpha, ss, and gamma. The protein has become of interest to the neuroscience community in the last few years after the discovery that a mutation in the alpha-synuclein gene is associated with familial autosomal-dominant early-onset forms of Parkinson Disease. However, it is not yet clear how the protein is involved in the disease. Several studies have suggested that alpha-synuclein plays a role in neurotransmitter release and synaptic plasticity. This hypothesis might help elucidate how alpha-synuclein malfunctioning contributes to the development of a series of disorders known as synucleinopathies.

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