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. 2003 Sep 15;188(6):873-82.
doi: 10.1086/377645. Epub 2003 Sep 4.

Presence of human immunodeficiency virus-1-specific CD4 and CD8 cellular immune responses in children with full or partial virus suppression

Emmanouil Papasavvas  1 , Johan K Sandberg, Richard Rutstein, Elizabeth C Moore, Agnieszka Mackiewicz, Brian Thiel, Maxwell Pistilli, Rayford R June, Kimberly A Jordan, Robert Gross, Vernon C Maino, Douglas F Nixon, Luis J Montaner
Affiliations

Presence of human immunodeficiency virus-1-specific CD4 and CD8 cellular immune responses in children with full or partial virus suppression

Emmanouil Papasavvas et al. J Infect Dis. .

Erratum in

  • J Infect Dis. 2003 Dec 15;188(12):1961

Abstract

The present study assessed antiviral T cell immune responses in 48 human immunodeficiency virus (HIV)-infected children with a stable or decreasing CD4(+) T cell counts and different levels of viral control, in the presence or absence of antiretroviral therapy. Children with full (<40 copies/mL) or partial (<50,000 copies/mL) virus suppression and with a history of stable CD4(+) T cell counts had significantly increased levels of anti-HIV CD4(+) T cell lymphoproliferative responses, lower levels of CD38(+), and higher CD8(+)/CD28(+) T cell percentage, compared with those in treated children with a lack of virus suppression (>50,000 copies/mL). Levels of anti-HIV CD8(+) T cell activity, although higher in treated children with a lack of virus suppression, were not significantly different between the groups. Although levels of anti-HIV CD4(+) and CD8(+) T cell responses were not associated, these levels of responses were associated with the percentage of specific T cell subsets. Overall, a history of stable CD4(+) T cell counts, as a result of therapy that imparted full or partial virus suppression, was associated with increased levels of anti-HIV CD4(+) T helper responses and decreased T cell activation.

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