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. 2003 Oct;10(10):843-8.
doi: 10.1038/nsb977. Epub 2003 Sep 7.

The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D

Christopher A Love  1 , Karl Harlos, Nasim Mavaddat, Simon J Davis, David I Stuart, E Yvonne Jones, Robert M Esnouf
Affiliations

The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D

Christopher A Love et al. Nat Struct Biol. 2003 Oct.

Abstract

Semaphorins, proteins characterized by an extracellular sema domain, regulate axon guidance, immune function and angiogenesis. The crystal structure of SEMA4D (residues 1-657) shows the sema topology to be a seven-bladed beta-propeller, revealing an unexpected homology with integrins. The sema beta-propeller contains a distinctive 77-residue insertion between beta-strands C and D of blade 5. Blade 7 is followed by a domain common to plexins, semaphorins and integrins (PSI domain), which forms a compact cysteine knot abutting the side of the propeller, and an Ig-like domain. The top face of the beta-propeller presents prominent loops characteristic of semaphorins. In addition to limited contact between the Ig-like domains, the homodimer is stabilized through extensive interactions between the top faces in a sector of the beta-propeller used for heterodimerization in integrins. This face of the propeller also mediates ligand binding in integrins, and functional data for semaphorin-receptor interactions map to the equivalent surface.

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