Review
doi: 10.1001/archneur.60.8.1045.
The hereditary spastic paraplegias: nine genes and counting
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- PMID: 12925358
- DOI: 10.1001/archneur.60.8.1045
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Review
The hereditary spastic paraplegias: nine genes and counting
Arch Neurol.
2003 Aug.
Abstract
The hereditary spastic paraplegias (HSPs) are inherited neurologic disorders in which the primary symptom is insidiously progressive difficulty walking due to lower extremity weakness and spasticity. There have been great strides in our knowledge of this group of disabling disorders; 20 HSP loci and 9 HSP genes have been discovered. Insights into the molecular causes of HSPs are beginning to emerge. This review summarizes these advances in HSPs' genetics.
Comment in
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Allan-Herndon-Dudley syndrome: should the locus for this hereditary spastic paraplegia be designated SPG 22?Arch Neurol. 2004 Sep;61(9):1470-1; author reply 1471. doi: 10.1001/archneur.61.9.1470-c. Arch Neurol. 2004. PMID: 15364700 No abstract available.
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