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. 2003;4(2):E13.
doi: 10.1208/pt040213.

Poly(D,L-lactide-co-glycolide) microspheres containing 5-fluorouracil: optimization of process parameters

Rajesh H Parikh  1 , Jolly R Parikh, Rajesh R Dubey, Heena N Soni, Kishor N Kapadia
Affiliations

Poly(D,L-lactide-co-glycolide) microspheres containing 5-fluorouracil: optimization of process parameters

Rajesh H Parikh et al. AAPS PharmSciTech. 2003.

Abstract

The objective of this research was to optimize the processing parameters for poly(D,L-lactide-co-glycolide) (PLGA) microspheres of 5-fluorouracil (5-FU) and to mathematically relate the process parameters and properties of microspheres. Microspheres were prepared by a water-in-oil-in-water emulsion solvent evaporation technique. A 3(2) factorial design was employed to study the effect of the volume of the internal phase of the primary emulsion and the volume of the external phase of the secondary emulsion on yield, particle size, and encapsulation efficiency of microspheres. An increase in the volume of the internal phase of the primary emulsion resulted in a decrease in yield and encapsulation efficiency and an increase in particle size of microspheres. When the volume of the external phase of the secondary emulsion was increased, a decrease in yield, particle size, and encapsulation efficiency was observed. Microspheres with good batch-to-batch reproducibility could be produced. Scanning electron microscopic study indicated that microspheres existed as aggregates.

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References

    1. Rolland A, Wagner N, Chatelus A, Shrout B, Schaefer H. Site specific delivery to pilosebaceous structures using polymeric microspheres. Pharm Res. 1993;10:1738–1774. doi: 10.1023/A:1018922114398. - DOI - PubMed
    1. Maze GI, Reinhart RA, Agrawal RK, et al. Response to intracervicular controlled delivery of 25% tetracycline from poly(lactide/glycolide) film strips in SPT patients. J Clin Periodontol. 1995;22:860–867. doi: 10.1111/j.1600-051X.1995.tb01785.x. - DOI - PubMed
    1. Calabresi P, Chabner BA. Chemotherapy of neoplastic diseases. In: Hardman JG, Limbird LE, editors. Goodman and Gillmans The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: Pergamon Press; 1996. pp. 1225–1232.
    1. Ogawa Y, Yamamoto M, Okada H, Yashiki T, Shimamoto T. A new technique to efficiently entrap leuprolide acetate into microparticles of polylactic acid or copoly(lactic/glycolic) acid. Chem Pharm Bull. 1988;36:1095–1103. - PubMed
    1. Conway BR, Oya AH. Double emulsion microencapsulation of proteins as model antigens using polylactide polymers: effect of emulsifiers on microsphere characteristics and release kinetics. Eur J Pharm Biopharm. 1996;42(1):42–48.

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