[Measurement of subsets of blood T lymphocyte in 93 patients with severe acute respiratory syndrome and its clinical significance]
- PMID: 12899766
[Measurement of subsets of blood T lymphocyte in 93 patients with severe acute respiratory syndrome and its clinical significance]
Abstract
Objective: To investigate the changes of subsets of blood T lymphocyte in patients with severe acute respiratory syndrome (SARS) and their clinical significance.
Methods: Subsets of blood T lymphocyte in 93 patients with SARS were detected by flow cytometer. The patients comprised 40 men and 53 women, aged 17 - 88 years (average 44 years). The results detected in 64 normal subjects and 50 patients with AIDS served as controls.
Results: The numbers of CD(3)(+), CD(4)(+), and CD(8)(+) lymphocytes all significantly decreased in acute phase of SARS patients compared with those in normal persons. Their findings was different from what we observed in patients with AIDS who had decreased CD(4)(+), but increased CD(8)(+) counts. The counts of CD(3)(+), CD(4)(+), and CD(8)(+) lymphocytes decreased more apparently in patients with critical SARS. All the five patients who died had CD(4)(+) counts less than 200/microl. As the patients' conditions improved, the counts of CD(3)(+), CD(4)(+), and CD(8)(+) gradually returned to normal.
Conclusion: The patients with SARS were found having damage of cellular immunity markedly.
Similar articles
-
Measurement of subgroups of peripheral blood T lymphocytes in patients with severe acute respiratory syndrome and its clinical significance.Chin Med J (Engl). 2003 Jun;116(6):827-30. Chin Med J (Engl). 2003. PMID: 12877788
-
[Difference and significance of T-lymphocyte subsets in differential diagnosis between severe acute respiratory syndrome and common atypical pneumonia].Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2004 Jun;18(2):137-41. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2004. PMID: 15340501 Chinese.
-
The relationship between serum interleukins and T-lymphocyte subsets in patients with severe acute respiratory syndrome.Chin Med J (Engl). 2003 Jul;116(7):981-4. Chin Med J (Engl). 2003. PMID: 12890366
-
[Dynamic changes of T-lymphocytes and immunoglobulins in patients with severe acute respiratory syndrome].Zhonghua Yi Xue Za Zhi. 2003 Jun 25;83(12):1014-7. Zhonghua Yi Xue Za Zhi. 2003. PMID: 12899772 Chinese.
-
[Dynamics of T lymphocyte subsets in SARS patients].Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003 Oct;25(5):525-8. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2003. PMID: 14650150 Chinese.
Cited by
-
Analysis of clinical features and early warning signs in patients with severe COVID-19: A retrospective cohort study.PLoS One. 2020 Jun 26;15(6):e0235459. doi: 10.1371/journal.pone.0235459. eCollection 2020. PLoS One. 2020. PMID: 32589691 Free PMC article.
-
Clinical features of probable severe acute respiratory syndrome in Beijing.World J Gastroenterol. 2005 May 21;11(19):2971-4. doi: 10.3748/wjg.v11.i19.2971. World J Gastroenterol. 2005. PMID: 15902739 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
