Machinery for protein sorting and assembly in the mitochondrial outer membrane
- PMID: 12891361
- DOI: 10.1038/nature01753
Machinery for protein sorting and assembly in the mitochondrial outer membrane
Abstract
Mitochondria contain translocases for the transport of precursor proteins across their outer and inner membranes. It has been assumed that the translocases also mediate the sorting of proteins to their submitochondrial destination. Here we show that the mitochondrial outer membrane contains a separate sorting and assembly machinery (SAM) that operates after the translocase of the outer membrane (TOM). Mas37 forms a constituent of the SAM complex. The central role of the SAM complex in the sorting and assembly pathway of outer membrane proteins explains the various pleiotropic functions that have been ascribed to Mas37 (refs 4, 11-15). These results suggest that the TOM complex, which can transport all kinds of mitochondrial precursor proteins, is not sufficient for the correct integration of outer membrane proteins with a complicated topology, and instead transfers precursor proteins to the SAM complex.
Comment in
-
Cell biology: moving inside membranes.Nature. 2003 Jul 31;424(6948):505-6. doi: 10.1038/424505a. Nature. 2003. PMID: 12891342 No abstract available.
Similar articles
-
Two modular forms of the mitochondrial sorting and assembly machinery are involved in biogenesis of alpha-helical outer membrane proteins.J Mol Biol. 2010 Feb 26;396(3):540-9. doi: 10.1016/j.jmb.2009.12.026. Epub 2009 Dec 22. J Mol Biol. 2010. PMID: 20026336
-
Cell biology: moving inside membranes.Nature. 2003 Jul 31;424(6948):505-6. doi: 10.1038/424505a. Nature. 2003. PMID: 12891342 No abstract available.
-
Protein translocase of the outer mitochondrial membrane: role of import receptors in the structural organization of the TOM complex.J Mol Biol. 2002 Feb 22;316(3):657-66. doi: 10.1006/jmbi.2001.5365. J Mol Biol. 2002. PMID: 11866524
-
Protein import into mitochondria.IUBMB Life. 2001 Sep-Nov;52(3-5):101-12. doi: 10.1080/15216540152845894. IUBMB Life. 2001. PMID: 11798021 Review.
-
New developments in mitochondrial assembly.Annu Rev Cell Dev Biol. 2004;20:309-35. doi: 10.1146/annurev.cellbio.20.010403.105057. Annu Rev Cell Dev Biol. 2004. PMID: 15473843 Review.
Cited by
-
Assembly of the β-Barrel Outer Membrane Proteins in Gram-Negative Bacteria, Mitochondria, and Chloroplasts.ISRN Mol Biol. 2012 Nov 20;2012:708203. doi: 10.5402/2012/708203. eCollection 2012. ISRN Mol Biol. 2012. PMID: 27335668 Free PMC article. Review.
-
Mitochondrial protein synthesis, import, and assembly.Genetics. 2012 Dec;192(4):1203-34. doi: 10.1534/genetics.112.141267. Genetics. 2012. PMID: 23212899 Free PMC article.
-
From evolution to pathogenesis: the link between β-barrel assembly machineries in the outer membrane of mitochondria and gram-negative bacteria.Int J Mol Sci. 2012;13(7):8038-8050. doi: 10.3390/ijms13078038. Epub 2012 Jun 28. Int J Mol Sci. 2012. PMID: 22942688 Free PMC article. Review.
-
Biogenesis of the mitochondrial Tom40 channel in skeletal muscle from aged animals and its adaptability to chronic contractile activity.Am J Physiol Cell Physiol. 2010 Jun;298(6):C1308-14. doi: 10.1152/ajpcell.00644.2008. Epub 2010 Jan 27. Am J Physiol Cell Physiol. 2010. PMID: 20107041 Free PMC article.
-
The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria.J Cell Biol. 2004 Jan 5;164(1):19-24. doi: 10.1083/jcb.200310092. Epub 2003 Dec 29. J Cell Biol. 2004. PMID: 14699090 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
