Review
doi: 10.1055/s-2003-40543.
[Oncolytic viruses for genetic therapy of gastrointestinal tumors]
[Article in
German]
Affiliations
- PMID: 12858239
- DOI: 10.1055/s-2003-40543
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Review
[Oncolytic viruses for genetic therapy of gastrointestinal tumors]
[Article in
German]
Z Gastroenterol.
2003 Jul.
Abstract
Gastroenterological oncology requires new strategies with new mechanisms of action and without cross-resistance to currently available treatment regimes. Virotherapy which is based on the employment of replication-competent viral vectors exhibiting strong oncolytic properties is such an approach currently under preclinical/clinical investigation. Techniques of molecular virology are required for further improvement of current vectors, particularly with respect to oncolytic activity, tumour selectivity, tumour spread capacity, and safety.
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