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. 2003 Jul;41(7):3158-62.
doi: 10.1128/JCM.41.7.3158-3162.2003.

Rotavirus diarrhea severity is related to the VP4 type in Mexican children

Felipe Mota-Hernández  1 , Juan José Calva, Claudia Gutiérrez-Camacho, Sofía Villa-Contreras, Carlos F Arias, Luis Padilla-Noriega, Héctor Guiscafré-Gallardo, María de Lourdes Guerrero, Susana López, Onofre Muñoz, Juan F Contreras, Roberto Cedillo, Ismael Herrera, Fernando I Puerto
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Rotavirus diarrhea severity is related to the VP4 type in Mexican children

Felipe Mota-Hernández et al. J Clin Microbiol. 2003 Jul.

Abstract

This report is of a community-based case control study to assess whether the severity of acute diarrhea by rotavirus (RV) in young children is associated with a particular VP7 (G) or VP4 (P) RV serotype. Five hundred twenty children younger than 2 years of age with diarrhea lasting less than 3 days were age and gender matched with 520 children with no diarrhea. The G and P serotypes were determined with specific monoclonal antibodies, and the VP4 serotype specificity in a subgroup was confirmed by genotyping. Infection with a G3 serotype led to a higher risk of diarrhea than infection with a G1 serotype. Infection with a G3-nontypeable-P serotype was associated with more severe gastroenteritis than infection with a G3 (or G1) P1A[8] serotype. A child with diarrhea-associated dehydration was almost five times more likely to be infected with a G3-nontypeable-P serotype than a child without dehydration (P < 0.001). Moreover, the two predominant monotypes within serotype P1A[8] had significantly different clinical manifestations. In this study, the severity of RV-associated diarrhea was related to different P serotypes rather than to G serotypes. The relationship between serotype and clinical outcomes seems to be complex and to vary among different geographic areas.

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